386-71-0

Usage

Uses

Used in Pharmaceutical Industry:
2-nitro-3-(trifluoromethyl)aniline is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of a wide range of organic compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-nitro-3-(trifluoromethyl)aniline serves as an essential intermediate, facilitating the production of compounds that can be utilized in the development of pesticides and other agricultural chemicals to enhance crop protection and yield.
Used in Dye Manufacturing:
2-nitro-3-(trifluoromethyl)aniline is employed as an intermediate in the manufacturing of dyes, where its unique structural features contribute to the creation of a diverse array of colorants for various applications, including textiles, plastics, and printing inks.
Used in Fine Chemicals Production:
2-nitro-3-(trifluoromethyl)aniline also plays a role in the production of fine chemicals, where its presence in the synthesis process can lead to the development of specialty chemicals used across different industries for their unique properties and functions.

Upstream product

• 384-22-5 2-nitrobenzotrifluoride 
• 351-36-0 N-acetyl-3-trifluoromethylbenzenamine 
• 387-19-9 N-(2-nitro-3-(trifluoromethyl)phenyl)acetamide 

Downstream Products

• 384-22-5 2-nitrobenzotrifluoride 
• 520-21-8 1,3-bis-(2-nitro-3-trifluoromethyl-phenyl)-triazene 
• 571-82-4 8-nitro-7-trifluoromethyl-quinoline 
• 4605-35-0 2-Nitro-3-trifluormethyl-diphenylamin 
• 668-28-0 3-Brom-2-nitro-trifluormethylbenzol 
• 1168155-58-5 N-(2-chloro-5-methoxyphenyl)-2-nitro-3-(trifluoromethyl)aniline 
• 1168155-40-5 N-{3-[3-(methylsulfonyl)phenoxy]phenyl}-2-nitro-3-(trifluoromethyl)aniline 
• 1168155-35-8 N-(3-methoxyphenyl)-2-nitro-3-(trifluoromethyl)aniline 
• 2267-96-1 2-Amino-3-trifluormethyl-diphenylamin 
• 343-19-1 N,N'-(3-trifluoromethyl-o-phenylene)-bis-acetamide 
• 389-61-7 5-trifluoromethyl-2,3-diphenylquinoxaline 
• 392-11-0 4-(trifluoromethyl)-1H-benzo[d]imidazole 
• 440-39-1 4-nitro-benzoic acid-(7-trifluoromethyl-[8]quinolyl ester) 
• 389-21-9 toluene-4-sulfonic acid-(7-trifluoromethyl-[8]quinolyl ester) 

Relevant academic research and scientific papers

SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted benzimidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists

A series of 1-(3-aryloxyaryl)benzimidazoles incorporating a sulfone substituent (6) was prepared. High affinity LXR ligands were identified (LXRβ binding IC50 values 10 nM), some with excellent agonist potency and efficacy in a functional assay of LXR activity measuring ABCA1 mRNA increases in human macrophage THP1 cells. The compounds were typically stable in liver microsome preparations and had good oral exposure in mice.

DIHYDROOROTATE DEHYDROGENASE INHIBITORS

The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.

Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.

Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides

A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of animation.