392-11-0 Usage
General Description
1H-Benzimidazole, 4-(trifluoromethyl)-(9CI) is a chemical compound that belongs to the benzimidazole class of organic compounds. It is also known by its chemical formula C8H5F3N2. This chemical is a potential antifungal agent and has been studied for its potential use in pharmaceutical applications. It is a white solid substance with a melting point of 155-157 degrees Celsius. The trifluoromethyl group on the benzimidazole ring makes it a useful building block in the synthesis of other organic compounds. 1H-Benzimidazole,4-(trifluoromethyl)-(9CI) is primarily used for research and development purposes in the pharmaceutical and chemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 392-11-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 392-11:
(5*3)+(4*9)+(3*2)+(2*1)+(1*1)=60
60 % 10 = 0
So 392-11-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H5F3N2/c9-8(10,11)5-2-1-3-6-7(5)13-4-12-6/h1-4H,(H,12,13)
392-11-0Relevant articles and documents
SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
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Paragraph 00296; 00302; 00490-00491, (2021/04/01)
The invention provides substituted benzimidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.
Selective C-H trifluoromethylation of benzimidazoles through photoredox catalysis
Gao, Guo-Lin,Yang, Chao,Xia, Wujiong
supporting information, p. 1041 - 1044 (2017/02/05)
The protocol presented here is a new strategy for visible light induced C-H trifluoromethylation at C4 of benzimidazoles using Togni's reagent in the presence of fac-Ir(ppy)3. Its advantages are its operational simplicity, mild reaction conditions, low catalyst loading and wide substrate scope in which electron-withdrawing, electron-donating groups and different protecting groups are tolerated.
