392-11-0

Usage

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazole,4-(trifluoromethyl)-(9CI) is used as a potential antifungal agent for its potential use in pharmaceutical applications. Its unique structure and properties make it a promising candidate for the development of new antifungal drugs.
Used in Chemical Industry:
1H-Benzimidazole,4-(trifluoromethyl)-(9CI) is used as a building block in the synthesis of other organic compounds. Its trifluoromethyl group on the benzimidazole ring provides a versatile platform for the creation of new chemical entities with potential applications in various fields.
Used in Research and Development:
1H-Benzimidazole,4-(trifluoromethyl)-(9CI) is used for research and development purposes in both the pharmaceutical and chemical industries. Its unique properties and potential applications make it an important compound for further exploration and innovation.

InChI:InChI=1/C8H5F3N2/c9-8(10,11)5-2-1-3-6-7(5)13-4-12-6/h1-4H,(H,12,13)

Upstream product

• 51-17-2 benzoimidazole 
• 2926-30-9 sodium triflate 
• 887144-97-0 Togni's reagent 
• 386-71-0 2-nitro-3-(trifluoromethyl)aniline 
• 2314-97-8 iodotrifluoromethane 
• 64-18-6 formic acid 
• 360-60-1 3-(trifluoromethyl)benzene-1,2-diamine 

Relevant academic research and scientific papers

SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted benzimidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

Visible-Light-Induced Trifluoromethylation of Highly Functionalized Arenes and Heteroarenes in Continuous Flow

We report a continuous-flow protocol for the trifluoromethylation of arenes, heteroarenes, and benzofused heterocycles. This photoredox methodology relies on the use of solid sodium trifluoromethanesulfinate (CF 3 SO 2 Na) as the trifluoromethylating agent and the iridium complex [Ir{dF(CF 3)ppy} 2 ](dtbpy)]PF 6 as the photoredox catalyst. A diverse set of highly functionalized heterocycles proved compatible with the methodology, and moderate to good yields were obtained within 30 minutes of residence time.

Selective C-H trifluoromethylation of benzimidazoles through photoredox catalysis

The protocol presented here is a new strategy for visible light induced C-H trifluoromethylation at C4 of benzimidazoles using Togni's reagent in the presence of fac-Ir(ppy)3. Its advantages are its operational simplicity, mild reaction conditions, low catalyst loading and wide substrate scope in which electron-withdrawing, electron-donating groups and different protecting groups are tolerated.

Photochemical Perfluoroalkylation of Imidazoles

Imidazole and its derivatives undergo facile trifluoromethylation or perfluoroalkylation, in methanol solution at ambient temperature, following radical dissociation of RFI by γ or UV irradiation.In the case of imidazole, attack occurs preferen