38608-98-9

Upstream product

• 201230-82-2 carbon monoxide 
• 589-87-7 1,4-bromoiodobenzene 
• 91-64-5 coumarin 
• 7099-87-8 4-bromophenylglyoxylic acid 

Downstream Products

• 1608160-93-5 7-(4-bromophenyl)-9-(methoxycarbonyl)-6H-benzo[c]chromen-6-one 
• 1608160-71-9 methyl 2-[3-(4-bromophenyl)-4-oxo-1,9b-dihydro-4H-furo[3,4-c]chromen-1-yl]acrylate 
• 1416572-93-4 (1S,10bS)-4-(4-bromophenyl)-1-ethyl-1-phenyl-1,10b-dihydropyrano[3,4-c]chromene-2,5-dione 
• 1416573-12-0 (1R,10bR)-4-(4-bromophenyl)-1-ethyl-1-phenyl-1,10b-dihydropyrano[3,4-c]chromene-2,5-dione 

Relevant academic research and scientific papers

Diacylation of coumarins by silver-catalyzed decarboxylative cross-coupling

A mild silver-catalyzed decarboxylative acylation of coumarins has been developed by using α-oxocarboxylic acids as acyl sources. This protocol provides an efficient and straightforward access to aroyl substituted coumarins in moderate to excellent yields with good selectivities. Furthermore, the reaction conditions were also applicable to quinolinones and naphthoquinones, affording the corresponding acylated heterocyclic compounds.

A Regioselective Approach to C3-Aroylcoumarins via Cobalt-Catalyzed C(sp 2)-H Activation Carbonylation of Coumarins

A new cobalt-catalyzed C-H bond activation of coumarins with aryl halides or pseudohalides and carbon monoxide insertion to give various 3-aroylcoumarin derivatives is described. It is the first time that CO as C1 feedstock is used as the coupling partners in cobalt-catalyzed regioselective coumarin C-H functionalization reactions. Upon activation with manganese powder, the Co catalyzes the C-H bond activation carbonylation reactions of aryl iodides, bromides, and even triflates under mild conditions, providing the regioselective aroylated products in moderate to good yields.