38609-04-0

Basic information

• Product Name: lithium 5-oxo-L-prolinate
• Synonyms: lithium 5-oxo-L-prolinate;(2S)-5-Oxopyrrolidine-2-carboxylic acid lithium salt;5-Oxo-L-proline lithium salt
• CAS NO: 38609-04-0
• Molecular Formula: C₅H₆NO₃*Li
• Molecular Weight: 135.04704
• EINECS: 254-036-9
• Mol File: 38609-04-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: lithium 5-oxo-L-prolinate(CAS DataBase Reference)
• NIST Chemistry Reference: lithium 5-oxo-L-prolinate(38609-04-0)
• EPA Substance Registry System: lithium 5-oxo-L-prolinate(38609-04-0)

Safety Data

• Hazardous Substances Data: 38609-04-0(Hazardous Substances Data)

Usage

Description

Lithium 5-oxo-L-prolinate is a chemical compound that combines lithium with the essential amino acid proline. It is recognized for its mood-stabilizing properties and is primarily utilized in the management of bipolar disorder. Lithium 5-oxo-L-prolinate operates by influencing the levels of specific neurotransmitters within the brain, thereby facilitating mood regulation and mitigating the intensity and recurrence of manic episodes. Additionally, ongoing research is exploring its potential neuroprotective and anti-inflammatory characteristics, suggesting possible applications in addressing neurodegenerative diseases and inflammatory conditions. While it offers therapeutic advantages, the use of lithium 5-oxo-L-prolinate necessitates cautious oversight by healthcare professionals due to its potential side effects.

Uses

Used in Pharmaceutical Industry:
Lithium 5-oxo-L-prolinate is used as a mood-stabilizing agent for the treatment of bipolar disorder, serving to regulate mood swings and decrease the occurrence and severity of manic episodes by modulating neurotransmitter levels in the brain.
Used in Neurodegenerative Disease Research:
Lithium 5-oxo-L-prolinate is being explored as a potential neuroprotective agent, with ongoing studies investigating its capacity to shield neurons and potentially slow the progression of neurodegenerative diseases.
Used in Inflammatory Condition Treatment:
Lithium 5-oxo-L-prolinate is also under investigation for its anti-inflammatory properties, with research looking into its potential to alleviate symptoms and treat inflammatory conditions by reducing inflammation at the cellular level.

Upstream product

• 98-79-3 2-L-pyrrolidone-5-carboxylic acid 
• 98-79-3 L-Pyroglutamic acid 

Relevant articles and documents

Metal Binding by Amino Acids: Preparation and Crystal Structures of Lithium, Sodium, and Potassium Hydrogen Bis-L-pyroglutamate

Lithium, sodium and potassium bis-L-pyroglutamate , , and , respectively, have been prepared by reaction of aqueous solutions of the metal hydroxides with L-pyroglutamic acid in the molar ratio 1:2, or in methanol.Crystalline samples of the salts could be obtained by slow evaporation of solutions of the salts in methanol.In the solid state, Li(L-pGlu)(L-pGluH) adopts a chain structure with the lithium atoms arranged in double strands.Adjacent metal centers are bridged by the carboxylate groups of the L-pGlu- ligands.The L-pGluH ligands are attached to the metal centers through the amide oxygen atoms.Na(L-pGlu)(L-pGluH) forms a three-dimensional coordination polymer with two half-occupied sodium positions, one L-pGlu- and one L-GluH ligand in the asymmetric unit.The carboxyl and carboxylate groups of the L-pGluH and the L-pGlu- ligands are bridging the sodium centers, giving rise to eight-membered rings, which consist of two sodium atoms, a carboxyl and a carboxylate group.The hydrogen atoms of the carboxyl group of the L-pGluH ligands are involved in strong hydrogen bonds between a carboxyl and an adjacent carboxylate oxygen atom.K(L-pGlu)(L-pGluH) adopts a layer structure with strands of potassium atoms.The metal centers are connected through bridging carboxyl and carboxylate groups of the L-pGluH and L-pGlu- ligands, respectively.The structure features eight-membered ring units comparable to those observed for Na(L-pGlu)(L-pGluH), again with the hydrogen atom of the carboxyl group engaged in a strong transannular hydrogen bond.The amide oxygen atoms of the L-pGlu- and the L-pGluH ligands are coordinated to the metal centers of adjacent coordination chains.The results of 1H- and 13C-NMR investigations of aqueous solutions of the compounds indicate extensive electrolytic dissociation in diluted solutions. Key Words: Hydrogen bis-L-pyroglutamates, lithium, sodium, potassium / Pyroglutamate coordination and conformation