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(5alpha,6alpha)-4,5-epoxy-3-methoxy-17-methylmorphinan-6-yl acetate is a complex organic compound belonging to the morphinan class, which is derived from the opium poppy plant. This specific compound features a 4,5-epoxy ring, a 3-methoxy group, and a 17-methyl substitution on the morphinan core structure. It is an acetate ester, indicating the presence of an acetate functional group. This chemical is known for its potent analgesic properties and is used in the synthesis of various opioids, including the well-known pain reliever heroin. Due to its strong pain-relieving effects and potential for abuse, it is a controlled substance in many countries.

3861-72-1

3861-72-1 Suppliers

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3861-72-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3861-72-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,6 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3861-72:
(6*3)+(5*8)+(4*6)+(3*1)+(2*7)+(1*2)=101
101 % 10 = 1
So 3861-72-1 is a valid CAS Registry Number.

3861-72-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name [(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl] acetate

1.2 Other means of identification

Product number -
Other names Acetyldihydrokodein [Czech]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3861-72-1 SDS

3861-72-1Downstream Products

3861-72-1Relevant academic research and scientific papers

Synthesis of 1-fluoro-substituted codeine derivatives

Hosztafi, Sándor,Marton, János

, p. 973 - 982 (2016)

Syntheses of new N-demethyl-N-substituted analogues (propyl, allyl) of 1-fluorocodeine and their 7,8-dihydro derivatives were described starting from codeine. 1-Fluoronorcodeine and 1-fluorodihydronorcodeine were prepared by N-demethylation with α-chloroethyl chloroformate from the corresponding 6-O-acetyl protected derivatives. 3-O-Demethylation of 1-fluorocodeine and 1-fluorodihydrocodeine with boron tribromide resulted in 1-fluoromorphine and 1-fluorodihydromorphine respectively. 1-Fluorodihydromorphine was acetylated to 3,6-di-O-acetyl-1-fluorodihydromorphine. 8-Fluoroapocodeine and N-propyl-8-fluoroapocodeine were synthesized from the appropriate 1-fluorocodeine derivatives by acid-catalyzed rearrangement.

Oxidative metabolism of dihydrocodeine in Dark-Agouti and Sprague-Dawley rat liver microsomes

Kirkwood,Nation,Reynolds,Somogyi,Sansom

, p. 299 - 303 (2007/10/03)

The oxidative metabolism of dihydrocodeine to nordihydrocodeine and dihydromorphine was studied in liver microsomes of female Dark-Agouti (cytochrome P450 2D1 (CYP2D1) deficient) and Sprague-Dawley rats. Evaluation of microsomal metabolism in these two rat strains is a useful in-vitro model to test possible substrates of polymorphic human cytochrome P450 2D6 (CYP2D6). Nordihydrocodeine formation rates were similar in both strains. Analysis of the Michaelis-Menten kinetics of dihydromorphine formation showed a significant difference (P -1 g-1) and intrinsic clearance (0.986; 19.5 mL min-1 g-1). In Sprague-Dawley liver microsomes, dihydromorphine formation was suppressed by the CYP2D1 inhibitors, quinine and quinidine, at concentrations which had no effect on nordihydrocodeine formation. These in-vitro findings indicate that in rat liver microsomes the cytochrome P450 system is involved in dihydrocodeine metabolism to dihydromorphine and nordihydrocodeine and that CYP2D1 is involved in the O-demethylation to dihydromorphine but not the N-demethylation to nordihydrocodeine. The results of this study are in agreement with recent in-vivo studies of dihydrocodeine metabolism in man which indicate CYP2D6 is the predominant enzyme catalysing dihydromorphine formation.