38610-74-1Relevant academic research and scientific papers
Acyloxybutadiene tricarbonyl iron complexes as enzyme-triggered CO-releasing molecules (ET-CORMs): A structure-activity relationship study
Romanski, Steffen,Kraus, Birgit,Guttentag, Miguel,Schlundt, Waldemar,Rücker, Hannelore,Adler, Andreas,Neud?rfl, J?rg-Martin,Alberto, Roger,Amslinger, Sabine,Schmalz, Hans-Günther
supporting information, p. 13862 - 13875 (2013/01/15)
A series of η4-acyloxycyclohexadiene-Fe(CO)3 complexes was prepared and fully characterized by spectroscopic methods including single crystal X-ray diffraction. For this purpose a new synthetic access to differently acylated 1,3- and 1,5-dienol-Fe(CO)3 complexes was developed. The enzymatically triggered CO release from these compounds was monitored (detection of CO through GC and/or by means of a myoglobin assay) and the anti-inflammatory effect of the compounds was assessed by a cellular assay based on the inhibition of NO-production by inducible NO synthase (iNOS). It was demonstrated that the properties (rate of esterase-triggered CO release, iNOS inhibition, cytotoxicity) of the complexes strongly depend on the substitution pattern of the π-ligand and the nature of the acyloxy substituent.
Anti-androgen compounds
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, (2008/06/13)
Compounds of the formula STR1 in which each R is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, hydroxy, cyano, or halo, and both R groups are identical and are symmetrically located; R 1 is C 1 -C 3 alkyl and R 2 is methyl, or R 1 and R 2 taken together are (CH 2 -- n in which n is an integer from 4 to 6; and (1) X c and X d are hydrogen, and the combination of X a and Y a and of X b and Y b each represents a double bond, subject to the limitation that, when R 1 is C 1 -C 3 alkyl and is other than methyl, X c, X d, and R 1 are all in an α-configuration; or (2) X a, X b, X c, X d, Y a, and Y b are hydrogen, subject to the limitation that both X c and X d are in an α-configuration, both X a and X b are in an α-configuration or in a β-configuration, and, R 1, when it is C 1 -C 3 alkyl, is in an α-configuration, are useful in inhibiting the action of androgens or are intermediates to such anti-androgen compounds.
