386211-68-3

Basic information

• Product Name: quinolactacin A
• Synonyms: quinolactacin A;1H-Pyrrolo[3,4-b]quinoline-1,9(4H)-dione, 2,3-dihydro-4-methyl-3-[(1R)-1-methylpropyl]-, (3S)-
• CAS NO: 386211-68-3
• Molecular Formula: C16H18N2O2
• Molecular Weight: 270.33
• Mol File: 386211-68-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: quinolactacin A(CAS DataBase Reference)
• NIST Chemistry Reference: quinolactacin A(386211-68-3)
• EPA Substance Registry System: quinolactacin A(386211-68-3)

Safety Data

• Hazardous Substances Data: 386211-68-3(Hazardous Substances Data)

Usage

Uses

Quinolactacin A is a TNFα and AChE inhibitor for proteomics research.

Upstream product

• 73-32-5 L-isoleucine 
• 2922-83-0 L-kynurenine 
• 485-80-3 S-adenosyl-L-methionine 
• 133565-39-6 (4S,5S)-ethyl 4-((tert-butoxycarbonyl)amino)-5-methyl-3-oxo-heptanoate 
• 548488-44-4 (3S,1'S)-(1'-methylpropyl)-4-methyl-9-oxo-1,3,4,9-tetrahydropyrrolo[3,4-b]quinoline-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Concise enantioselective syntheses of quinolactacins A and B through alternative winterfeldt oxidation

Enantioselective total syntheses of (+)-quinolactacin B and (+)-quinolactacin A2 through asymmetric Pictet-Spengler cyclization and KO2 oxidation-an alternative Winterfeldt condition-are described.

Engineered Biosynthesis of Fungal 4-Quinolone Natural Products

Quinolone-containing natural products are widely found in bacteria, fungi, and plants. The fungal quinolactacins, which are N-methyl-4-quinolones, display a wide spectrum of biological activities. Here we uncovered a concise nonribosomal peptide synthetase pathway involved in quinolactacin A biosynthesis from Penicillium by using heterologous reconstitution and in vitro enzymatic synthesis. The N-desmethyl analog of quinolactacin A was accessed through the construction of a hybrid bacterial and fungi pathway in the heterologous host.