386273-52-5

Upstream product

• 100-39-0 benzyl bromide 
• 70500-72-0 7-hydroxy-1H-quinolin-2-one 
• 92962-89-5 7-(benzyloxy)-3,4-dihydro-2(1H)-quinolinone 

Downstream Products

• 813432-29-0 4-(7-benzyloxy-quinoline-2-yloxy)butyric acid ethyl ester 
• 813432-37-0 4-[7-(3-benzyloxycarbonyl-propoxy)quinolin-2-yloxy]butyryl-Val-Leu-Val-OMe 
• 813432-33-6 4-(7-benzyloxy-quinoline-2-yloxy)butyryl-Val-Leu-Val-OMe 
• 813432-31-4 4-(7-benzyloxy-quinoline-2-yloxy)butyric acid 

Relevant academic research and scientific papers

Preparation method and application of N-(pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor

The invention discloses a cyclin-dependent kinase inhibitor. The cyclin-dependent kinase inhibitor comprises an N-(pyrimidine-2-yl) coumarin-7-amine derivative shown as a general formula (I). In-vitropharmacodynamic tests prove that the compound has a high-selectivity inhibition effect on CDK9 kinase, and can be applied to reducing or inhibiting the activity of CDK9 kinase in cells. The inventionalso discloses a preparation method of the inhibitor and application of the inhibitor in drugs for CDK family kinase mediated diseases, especially hyperproliferative diseases, virus-induced infectious diseases and cardiovascular diseases.

Oxidative Aromatization of 3,4-Dihydroquinolin-2(1 H)-ones to Quinolin-2(1 H)-ones Using Transition-Metal-Activated Persulfate Salts

Inorganic persulfate salts were identified as efficient reagents for the oxidative aromatization of 3,4-dihydroquinolin-2(1H)-ones through the activation of readily available transition metals, such as iron and copper. The feasible protocol conforming to the requirement of green chemistry was utilized in the preparation of the key intermediate (7-(4-chlorobutoxy)quinolin-2(1H)-one 2) of brexpiprazole in 80% isolated yield on a 100 g scale, and different quinolin-2(1H)-one derivatives with various functional groups were demonstrated in 52-89% yields.

New constrained "molecular tongs" designed to dissociate HIV-1 protease dimer

New "molecular tongs" based on naphthalene and quinoline scaffolds linked to two peptidic strands were synthesized. They were designed to prevent dimerization of HIV-1 protease by targeting the antiparallel β-sheet involving N- and C-termini of each monom

Inhibitors of prenyl-protein transferase

The present invention is directed to macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent