38628-52-3

Upstream product

• 38628-51-2 3-(4-carboxyphenyl)propionic acid 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 140-88-5 ethyl acrylate 
• 16642-94-7 (E)-4-cyanocinnamic acid 
• 105-07-7 4-cyanobenzaldehyde 
• 539-74-2 Ethyl 3-bromopropionate 
• 910248-12-3 (3-ethoxy-3-oxopropyl)boronic acid 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 125261-30-5 p-(ethoxycarbonyl)phenyl triflate 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 51934-41-9 4-iodobenzoic acid ethyl ester 

Downstream Products

• 38628-54-5 p-(3-Hydroxypropyl)-benzylalkohol-bis-p-nitrobenzoat 

Relevant academic research and scientific papers

HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME

The present invention provides compounds I and II and compositions thereof for use in the modulation of Hsp70. In some embodiments, the present invention provides a method for inhibiting Hsp70 activity. In some embodiments, the present invention provides a method of treating a subject suffering from or susceptible to a disease, disorder, or condition responsive to Hsp70 inhibition comprising administering to the subject a therapeutically effective amount of a provided compound. In some embodiments, the present invention provides a method for treating or preventing cancer in a subject suffering therefrom, comprising administering to a patient in need thereof a therapeutically effective amount of a provided compound.

Direct synthesis of ester-containing indium homoenolate and its application in palladium-catalyzed cross-coupling with aryl halide

An efficient method for the synthesis of ester-containing indium homoenolate via a direct insertion of indium into β-halo ester in the presence of CuI/LiCl was described. The synthetic utility of the indium homoenolate was demonstrated by palladium-cataly

Direct method for carbon-carbon bond formation: The functional group tolerant cobalt-catalyzed alkylation of aryl halides

(Figure Presented). A new protocol for the direct cobaltcatalyzed alkylation of aryl halides has been developed that proceeds smoothly in the presence of phosphanes or bipyridines as ligands with a variety of alkyl halides, including challenging alkyl electrophiles bearing β hydrogen atoms (see scheme). Sensitive functional groups are tolerated on both coupling partners, thus, significantly extending the general scope of transition-metal-catalyzed alkylation of aryl halides.

Method for producing alkyl-substituted aromatic and heteroaromatic compounds by cross-coupling alkyl boronic acids with aryl-or heteroaryl-halogenides or sulfonates under Pd catalysis in the presence of a ligand

The invention relates to a method for producing alkyl-substituted aromatic and heteroaromatic compounds by cross-coupling alkyl boronic acids with aryl- or heteroaryl-halogenides or with aryl- or heteroaryl-sulfonates in the presence of a catalyst and of a Br?nsted base in a solvent or solvent mixture.

CoBr2(Bpy): An efficient catalyst for the direct conjugate addition of aryl halides or triflates onto activated olefins

An efficient cobalt-catalyzed method devoted to the direct conjugate addition of functionalized aryl compounds onto Michael acceptors is described. The CoBr2(2,2′-bipyridine) complex appears to be an extremely suitable catalyst for the activation of a variety of aromatic reagents ranging from halides to triflates functionalized by reactive groups. This procedure allows for the synthesis of compounds resulting from 1,4-addition in good to excellent yields. The versatility of this original process represents a simple alternative to most known methods using organometallic reagents.

3-arylpropanoate esters through the palladium-catalyzed reaction of aryl halides with acrolein diethyl acetal

The reaction of aryl halides with acrolein diethyl acetal in the presence of Pd(OAc)2, n-Bu3N, and n-Bu4NCl in DMF at 90°C affords ethyl 3-arylpropanoates. A variety of functional groups are tolerated in the aryl halides, including ether, aldehyde, ketone, ester, nitrile, and nitro groups. ortho-Substituents do not hamper the reaction. 3-Arylpropanoate esters were isolated in good to excellent yields with many neutral, electron-rich and electron-poor aryl iodides and electron-poor aryl bromide. Neutral and electron-rich aryl bromides gave the desired ester in moderate yields.

Electrochemical vinylation of aryl and vinyl halides with acrylate esters catalyzed by cobalt bromide

A consumable anode process permits the electrochemical Heck reaction between aromatic or vinylic halides and acrylate esters using cobalt bromide as catalyst associated with bipyridine as ligand in a mixture of acetonitrile/triethylamine/pyridine as solvent.

Cobalt bromide as catalyst in electrochemical addition of aryl halides onto activated olefins

The consumable anode process permits the electrochemical arylation of activated olefins from functionalized aryl halides when cobalt halide is used as catalyst, either associated with bipyridine and pyridine as ligands in DMF as solvent, or with only pyridine in acetonitrile as solvent. (C) 2000 Published by Elsevier Science Ltd.

PYRAZOLES AS HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2 INHIBITORS

A class of novel pyrazoles is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock

Pyrazoles as human non-pancreatic secretory phospholipase A2 inhibitors

A class of novel pyrazoles is disclosed together with the use of such compounds for inhibiting sPLA2mediated release of fatty acids for treatment of conditions such as septic shock.