386285-43-4

Upstream product

• 167887-40-3 methyl (3S)-3-amino-3-(3,4-dimethoxyphenyl)propanoate 
• 90642-54-9 ethyl 7-iodo-2-heptynoate 
• 386285-40-1 (S)-4-(3,4-dimethoxyphenyl)-2-oxo-3,4,6,7,8,9-hexahydro-2H-quinolizine-1-carboxylic acid ethyl ester 

Downstream Products

• 386285-44-5 (2R,4S,9aS)-2-hydroxy-4-(3,4-dimethoxyphenyl)-decahydroquinolizidine 
• 68681-73-2 (-)-(2S,4S,9aS)-2-hydroxy-4-(3,4-dimethoxyphenyl)-decahydroquinolizidine 

Relevant academic research and scientific papers

Two-component method to enantiopure quinolizidinones and Indolizidinones. Total synthesis of (-)-lasubine II.

The reaction of iodides 1 and enantiopure beta-amino esters 2 mediated by potassium carbonate in acetonitrile at 65 degrees C provides quinolizidinones or indolizidinones 3, together with piperidines or pyrrolidines 4. Hydrolysis of 4 to the corresponding