38634-65-0Relevant academic research and scientific papers
Carbonyl 1,2-transposition through triflate-mediated a-amination
Wu, Zhao,Xu, Xiaolong,Wang, Jianchun,Dong, Guangbin
, p. 734 - 740 (2021/11/16)
To date, it remains challenging to selectively migrate a carbonyl oxygen within a given molecular scaffold, especially to an adjacent carbon. In this work, we describe a simple one- or two-pot protocol that transposes a ketone to the vicinal carbon. This approach first converts the ketone to the corresponding alkenyl triflate, which can then undergo the palladium- and norbornene-catalyzed regioselective a-amination and ipso-hydrogenation enabled by a bifunctional hydrogen and nitrogen donor. The resulting "transposed enamine" intermediate can subsequently be hydrolyzed to produce the 1,2-carbonyl-migrated product. This method allows rapid access to unusual bioactive analogs through late-stage functionalization.
Amide-Directed C?H Sodiation by a Sodium Hydride/Iodide Composite
Huang, Yinhua,Chan, Guo Hao,Chiba, Shunsuke
supporting information, p. 6544 - 6547 (2017/05/29)
A new protocol for amide-directed ortho and lateral C?H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds.
INDOLE-BASED COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME
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Paragraph 0144-0145; 0150-0151, (2016/12/22)
The present invention relates to an indole-based compound and an organic light emitting device using the same. The indole-based compound is represented by Chemical formula 1.COPYRIGHT KIPO 2015
Biarylphosphonite gold(I) complexes as superior catalysts for oxidative cyclization of propynyl arenes into indan-2-ones
Henrion, Guilhem,Chavas, Thomas E. J.,Le Goff, Xavier,Gagosz, Fabien
supporting information, p. 6277 - 6282 (2013/07/11)
Striking gold: A series of variously functionalized propynyl arenes was smoothly converted into indan-2-ones by a new gold(I)-catalyzed oxidative cyclization process. [LAu]NTf2 (Tf=trifluoromethanesulfonyl) is a superior catalyst both in terms of yield and kinetics for the present transformation. Copyright
HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA
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Page/Page column 94, (2010/02/12)
This invention relates to compounds of the formula (I) wherein J, M, G, m, X, R', R2, R4, R5, R6, R7, R8, R9, Y, n, z, and R" are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.
Novel (α,β-Epoxyalkyl)lithium Reagents via the Lithiation of Organyl-Substituted Epoxides
Eisch, John J.,Galle, James E.
, p. 4835 - 4840 (2007/10/02)
A series of epoxides bearing unsaturated organyl groups attached directly to the epoxy group was found to have sufficient kinetic acidity to undergo clean lithiation at low temperatures.Epoxides of the type is aryl, vinylic, acetylenic, alkoxycarbonyl, or cyano, were smoothly converted into by either t-BuLi or LDA in the temperature range of -80 to -115 deg C.The resulting (α,β-epoxyalkyl)lithium reagents could be transformed into a variety of substituted epoxides, such as R2C-CE(Un)-O, where E = D, R3Si, R3Sn, R, RCO, CO2H, or COH(R)2.In cases where Un is acyl, addition to the carbonyl, rather than lithiation, occurred preferentially.Attempted lithiations of aziridines and thiiranes led to extrusion of nitrogen and sulfur, respectively.Even the relatively stable intermediates generated at -90 deg C underwent carbenoid-like decomposition at higher temperatures to yield isomerization and intermolecular-insertion products.Observation of these processes gives direct corroboration of reaction mechanisms proposed for the base-promoted isomerizations of epoxides.
