38664-17-4

Upstream product

• 1540-38-1 3-(1-methylethyl)pentane-2,4-dione 
• 106-60-5 ALA 
• 815-57-6 3-Methyl-2,4-pentanedione 
• 123-54-6 acetylacetone 
• 5451-09-2 5-aminolevulinic acid hydrochloride 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 134200-69-4 Ethyl (Z)-4-acetyl-5-methyl-2-(3'-oxo-1',3'-diphenylprop-1'-enyl)-1H-pyrrole-3-propanoate 
• 134200-70-7 Ethyl (E)-4-acetyl-5-methyl-2-(3'-oxo-1',3'-diphenylprop-1'-enyl)-1H-pyrrole-3-propanoate 

Relevant academic research and scientific papers

Competing Knorr and Fischer-Fink pathways to pyrroles in neutral aqueous solution

A proposed chemical model for the prebiogenesis of tetrapyrrole macrocycles relies on the condensation of a 3-alkyl-substituted 2,4-diketone and an α-aminoketone to form a pyrrole equipped for subsequent self-condensation leading to porphyrinogens. The co

Discovery of pyrrole-indoline-2-ones as aurora kinase inhibitors with a different inhibition profile

A series of pyrrole-indolin-2-ones were synthesized, and their inhibition profile for Aurora kinases was studied. The potent compound 33 with phenylsulfonamido at the C-5 position and a carboxyethyl group at the C-3′ position selectively inhibited Aurora

Reaction of some diketones with 5-aminolevulinic acid in acid solution

Some 2,4-diketones react with 5-aminolevulinic acid in acid solution to form pyrroles. There are two modes of cyclisation, one leading to the Knorr and the other to the Fischer-Fink product. By a consideration of the products obtained from pentane-, hexane-, 3-methylpentane-, 3-isopropylpentane-, 3,3-dimethylpentane-, 1,1,1-trifluoropentane- 1,1,1,5,5,5-hexafluoro- pentane-2,4-dione and ethyl acetoacetate some generalisations concerning the formation of Knorr and Fischer-Fink products have been made. The reactions of 5-methyl-5-aminolevulinic acid with pentane- and 3-methylpentane-2,4-dione have also been examined. The relevance of these studies to the cyclic dimerisation of 5-aminolevulinic acid is discussed briefly.