38664-17-4

Basic information

• Product Name: 1H-Pyrrole-3-propanoic acid, 4-acetyl-5-methyl-
• Synonyms: 3-(4-Acetyl-5-methyl-pyrrol-3-yl)-propionsaeure;4-acetyl-3-(2-carboxyethyl)-5-methylpyrrole;3-acetyl-4-(2-carboxyethyl)-2-methylpyrrole;3-(4-acetyl-5-methyl-pyrrol-3-yl)-propionic acid
• CAS NO: 38664-17-4
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.21500
• Mol File: 38664-17-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 397.5±42.0 °C(Predicted)
• Density: 1.223±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Pyrrole-3-propanoic acid, 4-acetyl-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-propanoic acid, 4-acetyl-5-methyl-(38664-17-4)
• EPA Substance Registry System: 1H-Pyrrole-3-propanoic acid, 4-acetyl-5-methyl-(38664-17-4)

Safety Data

• Hazardous Substances Data: 38664-17-4(Hazardous Substances Data)

Upstream product

• 5451-09-2 5-aminolevulinic acid hydrochloride 
• 123-54-6 acetylacetone 
• 106-60-5 ALA 
• 815-57-6 3-Methyl-2,4-pentanedione 
• 1540-38-1 3-(1-methylethyl)pentane-2,4-dione 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 134200-69-4 Ethyl (Z)-4-acetyl-5-methyl-2-(3'-oxo-1',3'-diphenylprop-1'-enyl)-1H-pyrrole-3-propanoate 
• 134200-70-7 Ethyl (E)-4-acetyl-5-methyl-2-(3'-oxo-1',3'-diphenylprop-1'-enyl)-1H-pyrrole-3-propanoate 

Relevant articles and documents

Competing Knorr and Fischer-Fink pathways to pyrroles in neutral aqueous solution

A proposed chemical model for the prebiogenesis of tetrapyrrole macrocycles relies on the condensation of a 3-alkyl-substituted 2,4-diketone and an α-aminoketone to form a pyrrole equipped for subsequent self-condensation leading to porphyrinogens. The co

Reaction of some diketones with 5-aminolevulinic acid in acid solution

Some 2,4-diketones react with 5-aminolevulinic acid in acid solution to form pyrroles. There are two modes of cyclisation, one leading to the Knorr and the other to the Fischer-Fink product. By a consideration of the products obtained from pentane-, hexane-, 3-methylpentane-, 3-isopropylpentane-, 3,3-dimethylpentane-, 1,1,1-trifluoropentane- 1,1,1,5,5,5-hexafluoro- pentane-2,4-dione and ethyl acetoacetate some generalisations concerning the formation of Knorr and Fischer-Fink products have been made. The reactions of 5-methyl-5-aminolevulinic acid with pentane- and 3-methylpentane-2,4-dione have also been examined. The relevance of these studies to the cyclic dimerisation of 5-aminolevulinic acid is discussed briefly.