386715-35-1Relevant articles and documents
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase
Ruf, Sven,Hallur, Mahanandeesha Siddappa,Anchan, Nisha K.,Swamy, Indu N.,Murugesan, Karthikai Raj,Sarkar, Sayantani,Narasimhulu, Lokesh Kananti,Putta, V.P. Rama Kishore,Shaik, Shama,Chandrasekar, Devaraj Venkatapura,Mane, Vishal Subhash,Kadnur, Sanjay Venkatachalapathi,Suresh, Juluri,Bhamidipati, Ravi Kanth,Singh, Manvi,Burri, Raghunadha Reddy,Kristam, Rajendra,Schreuder, Herman,Czech, Joerg,Rudolph, Christine,Marker, Alexander,Langer, Thomas,Mullangi, Ramesh,Yura, Takeshi,Gosu, Ramachandraiah,Kannt, Aimo,Dhakshinamoorthy, Saravanakumar,Rajagopal, Sridharan
supporting information, p. 922 - 925 (2018/02/14)
Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the primary metabolite of NA by ～80% at 2 h when dosed in mice orally at 50 mg/kg.
Triazole compound with immunosuppression activity as well as preparation method and application thereof
-
, (2018/03/24)
The invention discloses a triazole compound with immunosuppression activity as well as a preparation method and application thereof, and belongs to the technical field of medicine synthesis. According to the technical scheme of the invention, the triazole compound with immunosuppression activity is of a structure as shown in the specification. The invention further discloses a preparation method of the triazole compound with immunosuppression activity. The triazole compound with immunosuppression activity is synthesized by using a novel method, and is simple and feasible in operation in the reaction process, cheap and easy in raw material obtaining, relatively high in reaction velocity, relatively good in repeatability, and remarkable in immunosuppression activity.
Having a three-nitrogen azoles ring structure of immunosuppressant drug synthesis method
-
Paragraph 0038; 0039; 0040, (2018/04/01)
The invention discloses a has three nitrogen azoles ring structure of immunosuppressant drug synthesis method, which belongs to the technical field of medical synthesis. Technical proposal of the invention points are: having a three-nitrogen azoles ring structure immunosuppressive drug, has the following structure: The invention also discloses the has three nitrogen azoles ring structure of immunosuppressant drug preparation method. The invention through a new synthesis method with three nitrogen azoles ring structure the immunosuppressant drug, the reaction process is simple and easy operation, the raw material is cheap, relatively high reaction efficiency and good repeatability, the immunosuppressant drug active effect is obvious.
Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide
Battilocchio, Claudio,Hawkins, Joel M.,Ley, Steven V.
supporting information, p. 1060 - 1063 (2016/10/17)
A sustainable flow chemistry process for the hydration of nitriles, whereby an aqueous solution of the nitrile is passed through a column containing commercially available amorphous manganese dioxide, has been developed. The product is obtained simply by concentration of the output stream without any other workup steps. The protocol described is rapid, robust, reliable, and scalable, and it has been applied to a broad range of substrates, showing a high level of chemical tolerance.
