231291-22-8

Basic information

• Product Name: 6-(Trifluoromethyl)nicotinic acid
• Synonyms: 6-(TRIFLUOROMETHYL)NICOTINIC ACID;3-Pyridinecarboxylicacid, 6-(trifluoroMethyl)-;6-(Trifluoromethyl)pyridine-3-carboxylic acid, 5-Carboxy-2-(trifluoromethyl)pyridine;6- threefluorine Methylnicotinate;6-Trifluoromethylnicotic acid;6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID;2-TRIFLUOROMETHYL-5-PYRIDINECARBOXYLIC ACID;RARECHEM AL BO 1001
• CAS NO: 231291-22-8
• Molecular Formula: C₇H₄F₃NO₂
• Molecular Weight: 191.11
• EINECS: 1312995-182-4
• Product Categories: Nitrogen cyclic compounds;Pyridine Series;Acids and Derivatives;Heterocycles;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Carboxylic Acids;Pyridines;Pyridine;Niacin;Pyridines derivates;Heterocycle;Carboxylic Acids;Building Blocks;Aromatics
• Mol File: 231291-22-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 193-197 °C(lit.)
• Boiling Point: 259.322 °C at 760 mmHg
• Flash Point: 110.634 °C
• Appearance: white solid
• Density: 1.485 g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Acetonitrile (Slightly), Methanol (Slightly)
• PKA: 2.96±0.10(Predicted)
• CAS DataBase Reference: 6-(Trifluoromethyl)nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(Trifluoromethyl)nicotinic acid(231291-22-8)
• EPA Substance Registry System: 6-(Trifluoromethyl)nicotinic acid(231291-22-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 231291-22-8(Hazardous Substances Data)

Usage

Physical properties

6-Trifluoromethylnicotinic acid is a white powder with a melting point of 193-197 °C. It has a boiling point of 259.3℃ at 760 mmHg. Its density is 1.484 g/cm3. Its flash point, refractive index and vapor pressure are 110.6℃, 1.475 and 0.007mmHg at 25°C, respectively.

Uses

6-Trifluoromethyl Nicotinic Acid can be prepared to use Raf inhibitors to treat cancer.

InChI:InChI=1/C7H4F3NO2/c8-7(9,10)5-2-1-4(3-11-5)6(12)13/h1-3H,(H,12,13)

Upstream product

• 64-19-7 acetic acid 
• 216431-85-5 6-(trifluoromethyl)nicotinonitrile 
• 223463-13-6 2-iodo-5-bromopyridine 
• 30766-11-1 5-bromoisonicotinic acid 
• 624-28-2 2,5-dibromopyridine 
• 124-38-9 carbon dioxide 
• 368-48-9 2-(trifluoromethyl)pyridine 
• 436799-32-5 5-bromo-2(trifluoromethyl)pyridine 

Downstream Products

• 869794-18-3 [(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone 
• 1599531-72-2 C₃₁H₂₄ClF₆N₅O 
• 1599531-73-3 C₃₁H₂₄ClF₆N₅O 
• 1599531-33-5 C₃₅H₃₁F₃N₈O 
• 1599531-34-6 C₃₅H₃₁F₃N₈O 
• 1599531-88-0 C₃₃H₂₃F₃N₈O 
• 1599531-89-1 C₃₃H₂₃F₃N₈O 
• 1599531-82-4 C₃₁H₂₃ClF₄N₆O₂ 
• 1599531-83-5 C₃₁H₂₃ClF₄N₆O₂ 
• 1599529-25-5 C₃₂H₂₆ClF₃N₆O₂ 
• 1599529-85-7 C₃₂H₂₆ClF₃N₆O₂ 
• 1599531-71-1 (2-(azetidin-1-yl)-4-chloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol 
• 1599531-11-9 (3-(4-(1H-pyrazol-1-yl)benzyl)-2,4-dichloro-8-methylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol 
• 1599531-31-3 3-(4-(1H-pyrazol-1-yl)benzyl)-2-(diethylamino)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-4-carbonitrile 

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