386715-52-2

Basic information

• Product Name: 2-(METHYLSULFONYL)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANONE
• Synonyms: 4-(METHYLSULFONYLACETYL)BENZOTRIFLUORIDE;4-(METHYLSULPHONYLACETYL)BENZOTRIFLUORIDE;2-(METHYLSULFONYL)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANONE;1-[4-(TRIFLUOROMETHYL)BENZOYL]DIMETHYLSULFONE;1-4[-(TRIFLUOROMETHYL)FLUOROPHENYL]-2-(METHYLSULFONYL)ETHANONE;1-[4-(TRIFLUOROMETHYL)BENZOYL]DIMETHYLSULPHONE
• CAS NO: 386715-52-2
• Molecular Formula: C₁₀H₉F₃O₃S
• Molecular Weight: 266.24
• Mol File: 386715-52-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 100-102°C
• Boiling Point: 419.3 °C at 760 mmHg
• Flash Point: 207.4 °C
• Appearance: /
• Density: 1.386g/cm³
• Vapor Pressure: 3.06E-07mmHg at 25°C
• Refractive Index: 1.48
• CAS DataBase Reference: 2-(METHYLSULFONYL)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLSULFONYL)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANONE(386715-52-2)
• EPA Substance Registry System: 2-(METHYLSULFONYL)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANONE(386715-52-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 386715-52-2(Hazardous Substances Data)

Usage

General Description

2-(Methylsulfonyl)-1-[4-(trifluoromethyl)phenyl]ethanone, also known as Finasteride, is a medication primarily used to treat an enlarged prostate and male pattern hair loss. It works by blocking the production of a hormone that causes the prostate to grow. As a result, it can help improve symptoms such as difficulty urinating and reduce the risk of developing acute urinary retention or the need for surgery. It is also used to restore hair growth in men with male pattern baldness. However, it is not approved for use in women or children. This chemical compound is classified as a 5-alpha-reductase inhibitor and is available in various forms, including tablets and topical solutions.

InChI:InChI=1/C10H9F3O3S/c1-17(15,16)6-9(14)7-2-4-8(5-3-7)10(11,12)13/h2-5H,6H2,1H3

Upstream product

• 67-71-0 dimethylsulfone 
• 2967-66-0 methyl 4-(trifluoromethyl)benzoate 
• 705-31-7 4-trifluoromethylphenylacetylene 
• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 
• 67-68-5 dimethyl sulfoxide 

Downstream Products

• 1599463-36-1 (Z)-N-(2-(methylsulfonyl)-1-(4-(trifluoromethyl)phenyl)vinyl)acetamide 

Relevant articles and documents

Visible-light-promoted aerobic oxidative synthesis of β-ketosulfones under photocatalyst-free conditions

A simple and convenient visible-light-mediated method has been developed for the construction of β-ketosulfones via aerobic oxidative difunctionalization of alkynes with arylazo sulfones and dioxygen in air under photocatalyst-free conditions. The present photochemical methodology provides a facile and attractive protocol to construct a series of β-ketosulfones in moderate to good yields.

Photocatalyst-Free Visible Light-Induced Synthesis of β-Oxo Sulfones via Oxysulfonylation of Alkenes with Arylazo Sulfones and Dioxygen in Air

A catalyst-free strategy has been established for the synthesis of β-oxo sulfones via visible light-induced oxysulfonylation of alkenes with arylazo sulfones with dioxygen in air. The present photoinduced transformation proceeds smoothly at room temperature in the absence of an external photosensitizer, which not only provides a mild and efficient approach to various β-oxo sulfones, but also opens a different reaction mode for the photochemical reaction of arylazo sulfones.

CO/O2 assisted oxidative carbon-carbon and carbon-heteroatom bond cleavage for the synthesis of oxosulfonates from DMSO and olefins

Selective carbon-carbon and carbon-heteroatom bond cleavage was achieved in a one reaction system. With this strategy a novel Pd/Cu-catalyzed aerobic oxidative oxosulfonation of olefins with DMSO has been developed. Preliminary mechanistic investigations indicated that CO/O2 assisted the bond cleavage and the leaving groups from the starting materials were trapped by O2 and underwent a hydroxylation process.