386739-99-7Relevant academic research and scientific papers
Divergent modes of enzyme inhibition in a homologous structure-activity series
Ferreira, Rafaela S.,Bryant, Clifford,Ang, Kenny K. H.,McKerrow, James H.,Shoichet, Brian K.,Renslo, Adam R.
supporting information; experimental part, p. 5005 - 5008 (2010/02/28)
A docking screen identified reversible, noncovalent inhibitors (e.g., 1) of the parasite cysteine protease cruzain. Chemical optimization of 1 led to a series of oxadiazoles possessing interpretable SAR and potencies as much as 500-fold greater than 1. De
