38675-31-9

Basic information

• Product Name: 4-PHENYLPYRIMIDIN-2-OL
• Synonyms: 4-PHENYLPYRIMIDIN-2-OL
• CAS NO: 38675-31-9
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18
• Mol File: 38675-31-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-PHENYLPYRIMIDIN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYLPYRIMIDIN-2-OL(38675-31-9)
• EPA Substance Registry System: 4-PHENYLPYRIMIDIN-2-OL(38675-31-9)

Safety Data

• Hazardous Substances Data: 38675-31-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
4-Phenylpyrimidin-2-ol is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the formation of diverse chemical entities through reactions such as nucleophilic substitution, electrophilic substitution, and condensation reactions.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-Phenylpyrimidin-2-ol is utilized as a building block for the development of new drug molecules. Its presence in the molecular structure can impart specific biological activities and pharmacological properties, making it a valuable component in the design and synthesis of potential therapeutic agents.
Used in Drug Discovery and Development:
4-Phenylpyrimidin-2-ol is a subject of interest in drug discovery and development due to its potential biological activities. Researchers are exploring its interactions with biological targets and evaluating its efficacy in treating various diseases. 4-PHENYLPYRIMIDIN-2-OL's ability to modulate cellular processes and pathways may contribute to the development of novel therapeutic agents.
Overall, 4-Phenylpyrimidin-2-ol is a versatile chemical with diverse potential applications in various fields of science and technology, including organic chemistry, pharmaceutical research, and drug discovery and development. Its unique structure and potential biological activities make it a valuable asset in the synthesis of new compounds and the development of innovative therapeutic agents.

Upstream product

• 13036-50-5 2-chloro-4-phenylpyrimidine 
• 15397-33-8 3-Oxo-3-phenylpropanal 
• 2305-87-5 4-phenylpyrimidin-2-amine 
• 768-03-6 Phenyl vinyl ketone 
• 58006-76-1 4,7-dihydro-5-phenyl-1,2,4-oxadiazepin-3(2H)-one 
• 98-80-6 phenylboronic acid 

Downstream Products

• 13036-50-5 2-chloro-4-phenylpyrimidine 
• 762302-95-4 1-(4-chlorobutyl)-4-phenylpyrimidin-2(1H)-one 
• 14079-89-1 6-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1250869-81-8 4-phenyltetrahydropyrimidin-2(1H)-one 
• 1277150-38-5 (R)-(+)-4-phenyltetrahydropyrimidin-2(1H)-one 

Relevant articles and documents

Identification of N-arylsulfonylpyrimidones as anticancer agents

For confirming the role of five membered ring of imidazolidinone moiety of N-arylsulfonylimidazolidinones (7) previously reported with highly potent anticancer agent, a series of N-arylsulfonylpyrimidones (10a–g) and N-arylsulfonyltetrahydropyrimidones (11a–e) were prepared and their anti-proliferating activity was measured against human cancer cell lines (renal ACHN, colon HCT-15, breast MDA-MB-231, lung NCI-H23, stomach NUGC-3, and prostate PC-3) using XTT assay. Among them, 1-(1-acetylindolin-5-ylsulfonyl)-4-phenyltetrahydropyrimidin-2(1H)-one (11d, mean GI50?=?3.50?μM) and ethyl 5-(2-oxo-4-phenyltetrahydropyrimidin-1(2H)-ylsulfonyl)-indoline-1-carboxylate (11e, mean GI50?=?0.26?μM) showed best growth inhibitory activity against human cancer cell lines. Considering the activity results, N-arylsulfonyltetrahydropyrimidones (11) exhibited more potent activity compared to N-arylsulfonylpyrimidones (10) and comparable activity to N-arylsulfonylimidazolidinones (7). Especially, tetrahydropyrimidin-2(1H)-one analogs containing acylindolin-5-ylsulfonyl moiety at position 1 demonstrated their strong growth inhibitory activity against human cancer cell lines.

Compounds with cardiac myosin activating function and pharmaceutical composition containing the same for treating or preventing heart failure

The present invention relates to a compound having a cardiotonic activating function and a pharmaceutical composition containing the same. The composition comprising the compound according to the present invention is effective in preventing or treating heart failure. In addition, the compound is represented by chemical formula 2 or is pharmaceutically acceptable salt thereof.COPYRIGHT KIPO 2016

Compounds with cardiac myosin activating function and pharmaceutical composition containing the same for treating or preventing heart failure

Disclosed are a compound having cardiotonic activity and a pharmaceutical composition containing the same, and the composition containing the compound, according to the present invention, is useful for preventing and treating heart failure.COPYRIGHT KIPO 2016

Synthesis and SAR of highly potent and selective dopamine D 3-receptor antagonists: 1H-Pyrimidin-2-one derivatives

The synthesis and SAR of novel highly potent and selective dopamine D 3-receptor antagonists based on a 1H-pyrimidin-2-one scaffold are described. A-690344 antagonized PD 128907-induced huddling deficits in rat (ED50 6.1 mg/kg po), a social interaction paradigm.

SYNTHESIS OF SUBSTITUTED 2- AND 4-HYDROXYAMINOPYRIMIDINES

The reaction of 2- and 4-chlorine-containing alkyl(aryl)pyrimidines with hydroxylamine was studied.It was shown that, depending on the amount of hydroxylamine , N,O-dipyrimidinylhydroxyamides or the corresponding 2- and 4-hydroxyaminopyrimidines are formed together with 2- and 4-oxodihydropyrimidines.

Transformations of 2-Aminopyrimidines and Their N-Oxides under Diazotation Conditions

The diazotation of 2-aminopyrimidines and their N-oxides in solutions with various acidities was studied.It is shown that the amino group in pyrimidine N-oxides is not diazotized in strongly acidic media and that bromination in the 5 position of the pyrimidine ring is observed in concentrated hydrobromic acid.When the reaction was carried out in moderately acidic media, it was possible to synthesize the difficult-to-obtain 2-halopyrimidine N-oxides.

REACTIVITY OF 4,7-DIHYDRO-5-PHENYL-1,2,4-OXADIAZEPIN-3(2H)-ONES

The reactions of 4,7-dihydro-5-phenyl-1,2,4-oxadiazepin-3(2H)-ones have been studied.The behaviour of this unsaturated, seven-membered heterocyclic series, which possesses an O-NH-CO-NH functionality, depends on the reagents employed, the experimental con