38680-83-0

Usage

Uses

Used in Pharmaceutical Industry:
Dexamethasone is used as an anti-inflammatory and immunosuppressive agent for the treatment of various conditions, such as rheumatoid arthritis, lupus, asthma, and allergies. Its potent anti-inflammatory effects make it an effective treatment for reducing inflammation and alleviating symptoms associated with these conditions.
Used in Oncology:
Dexamethasone is employed as an adjunct therapy in the treatment of certain types of cancer, particularly hematological malignancies and brain tumors. It helps to reduce inflammation and swelling associated with cancer, as well as modulating the immune system to enhance the effectiveness of other cancer treatments.
Used in Hormone Replacement Therapy:
In cases of adrenal insufficiency, Dexamethasone is used as a hormone replacement therapy to help restore normal hormone levels in the body. This helps to alleviate symptoms and maintain overall health in individuals with adrenal insufficiency.
Used in Ophthalmology:
Dexamethasone is utilized in the form of eye drops or ointments to treat various eye conditions, such as inflammation, allergies, and post-operative inflammation following eye surgeries. Its anti-inflammatory and immunosuppressive properties help to reduce swelling, redness, and discomfort in the eyes.
Used in Dermatology:
Dexamethasone is applied topically as an ointment or cream to treat various skin conditions, including eczema, psoriasis, and contact dermatitis. Its anti-inflammatory and immunosuppressive effects help to reduce inflammation, itching, and redness associated with these skin conditions.

Upstream product

• 4224-31-1 21-acetoxy-9-bromo-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione 
• 96465-68-8 21-acetoxy-9-bromo-11β-formyloxy-17-hydroxy-pregna-1,4-diene-3,20-dione 
• 378-35-8 21-acetoxy-9-bromo-17-hydroxy-11β-trifluoroacetoxy-pregna-1,4-diene-3,20-dione 
• 52-21-1 prednisolone 21-acetate 
• 4380-55-6 pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate 
• 898-84-0 11α-hydroxy-androsta-1,4-diene-3,17-dione 
• 127-08-2 potassium acetate 
• 15375-21-0 androsta-1,4,9⁽¹¹⁾-triene-3,17-dione 
• 7753-60-8 anecortave 

Downstream Products

• 338-98-7 isoflupredone acetate 
• 426-20-0 9-fluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione 
• 338-95-4 isoflupredone 
• 382-66-1 9-fluoro-11β,17-dihydroxy-21-methanesulfonyloxy-pregna-1,4-diene-3,20-dione 
• 72498-89-6 17α, 21-diacetyloxy-9β,11β-epoxy-6α-fluoro-1,4-diene-3,20-dione 
• 2326-26-3 acetic acid 2-((6S,8S,9R,10S,11S,13S,14S)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthrene-17-yl)-2-oxo-ethyl ester 
• 4306-83-6 21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione 
• 356-12-7 fluocinonide 
• 67-73-2 fluocinolone Acetonide 
• 52-70-0 21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione 

Relevant academic research and scientific papers

Preparation method of 6alpha, 9alpha-difluoroprednisolone

The invention belongs to the technical field of steroid hormone preparation, and particularly relates to a preparation method of 6alpha, 9alpha-difluoroprednisolone. Anecortave dehydroacetate used asa starting raw material undergoes bromo-hydroxy epoxidation, 6-positon fluoridation, 9-position fluoridation and hydrolysis to prepare the 6alpha, 9alpha-difluoroprednisolone. The method taking the anecortave dehydroacetate as the starting raw material has the advantages of low prices, few isomers, few impurities and short reaction route.

Improved synthesis of fluocinolone acetonide and process research of 6α,9α-fluorination

An efficient and improved synthetic route of fluocinolone acetonide with combination of bio-fermentation was developed from 21-acetyloxy-17α-hydroxy-4,9(11)-diene-3,20-dione (1a). Process of the 6α and 9α fluorination steps was studied, and it was observe

A process for the preparation of intermediates fluocinone acetate

The invention discloses a preparation method for a fluocinolone acetonide midbody, i.e., 21-acetate-9,11-epoxy-17-alpha-hydroxypregn-1,4-diene-3,20-diketone. A compound I, i.e., 11-alpha-hydroxy-ADD (androstadienedione), serves as a starting material; an elimination reaction, a cyano-substitution reaction, a siloxy protective reaction, an intramolecular nucleophilic substitution reaction, a bromo-epoxy reaction and a replacement reaction are carried out to obtain the fluocinolone acetonide midbody. The preparation method provided by the invention has the advantages that the starting material which is relatively cheap is used, the reactions in the steps are relatively easy to implement, and the yield is higher, so that the production is more economical and safe, and higher applicability for industrial production is achieved; through route design optimization, the preparation method avoids 9 (11)-double-bonded epoxidation with the existence of 21-acetate in the traditional technique, so as to avoid the 21-acetate hydrolysis, greatly improve the quality and yield of the fluocinolone acetonide midbody, and reduce the entire production cost.

Acyclic amine epoxide process

Acyclic amines are used to transform 9α-substituted-11β-hydroxy 21-acyloxy steroids to the corresponding 9β,11β-epoxy 21-acyloxy steroids without removal of the C17 or C21 ester. The acyclic amines are cheaper and easier to prepare than previously disclosed dehydrohalogenating agents which do not produce cleavage of the C21 ester.