4306-83-6 Usage
General Description
6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate is a synthetic corticosteroid and derivative of the naturally occurring hormone cortisol. It is a potent anti-inflammatory and immunosuppressive agent that is commonly used to treat a variety of inflammatory conditions such as arthritis, asthma, and allergic reactions. This chemical functions by inhibiting the production of prostaglandins and other inflammatory mediators, leading to a reduction in inflammation and immune response. It is often administered orally or topically, and its use may be associated with side effects such as weight gain, fluid retention, and increased susceptibility to infections.
Check Digit Verification of cas no
The CAS Registry Mumber 4306-83-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,0 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 4306-83:
(6*4)+(5*3)+(4*0)+(3*6)+(2*8)+(1*3)=76
76 % 10 = 6
So 4306-83-6 is a valid CAS Registry Number.
4306-83-6Relevant articles and documents
Novel secosteroids arising from acid catalysed rearrangement of fluocinonide acetonide in the presence of Tf2O and TMSOTf
Procopiou, Panayiotis A.,Lynn, Sean M.,Roberts, Andrew D.
, p. 3649 - 3656 (1999)
Treatment of 6α,9α-difluoro-11β,21-dihydroxy-3,20-dioxo-16α, 17α- isopropylidenedioxypregna-1,4-diene-21-yl acetate (fluocinonide acetonide) with trifluoromethanesulfonic anhydride in the presence of trimethylsilyl trifluoromethanesulfonate as catalyst gave the ketone 3 and furan 4 arising from cleavage of the C9-C10 bond and aromatisation of the A ring, and fluocinonide 5. The ketone 3 was shown to be an intermediate in the formation of furan 4.
Improved synthesis of fluocinolone acetonide and process research of 6α,9α-fluorination
Tang, Jie,Zeng, Chunling,Xie, Longyong,Wang, Jinghua,Tian, Mi,Guo, Cancheng
, p. 110 - 112 (2018/01/26)
An efficient and improved synthetic route of fluocinolone acetonide with combination of bio-fermentation was developed from 21-acetyloxy-17α-hydroxy-4,9(11)-diene-3,20-dione (1a). Process of the 6α and 9α fluorination steps was studied, and it was observe
