38694-34-7

Usage

Type of Compound

Organic compound

Functional Group

Ketone

Chlorine Attachment

Attached to the third carbon of the carbon chain

2-Methoxyphenyl Group

Attached to the second carbon

Applications

a. Synthesis of pharmaceuticals
b. Synthesis of agrochemicals
c. Other organic compounds
d. Reagent in chemical reactions
e. Building block in organic synthesis

Physical State

Liquid

Flammability

Flammable liquid

Safety Precautions

a. Avoid contact with skin
b. Avoid contact with eyes
c. Use appropriate protective equipment when handling

Potential Hazards

a. Skin irritation
b. Eye irritation

Upstream product

• 7169-17-7 2-diazo-1-(2-methoxyphenyl)ethanone 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 93-25-4 2-methoxyphenylacetic acid 
• 28033-63-8 2-(2-methoxyphenyl)acetyl chloride 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 124067-29-4 3-(2-anisyl)-α-diazo-2-propanone 

Downstream Products

• 1114770-37-4 4-(2-methoxybenzyl)-2-(4-(4-methoxyphenylsulfonyl)piperazin-1-yl)thiazole 

Relevant academic research and scientific papers

One-step synthesis of 1-chloro-3-arylacetone derivatives from arylacetic acids

A practical one-step method has been developed to prepare α-chloroketones from readily available, inexpensive phenylacetic acid derivatives. The method utilizes the unique reactivity of an intermediate Mg.enolate dianion, which displays selectivity for the carbonyl carbon of chloromethyl carbonyl electrophiles. Decarboxylation of the intermediate occurs spontaneously during the reaction quench. The utility of the reaction products has been demonstrated through the total synthesis of the natural product cimiracemate B.

N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES

This invention provides thiazolylpiperazine derivatives, and N-sulfonyl heterocyclic derivatives including phenyl- and benzyl-thiazolylpiperidine derivatives, and pharmaceutically acceptable salts thereof, which are useful active ingredients for administration in a method for the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides methods for making such derivatives, and pharmaceutical compositions including such derivatives together with pharmaceutically acceptable excipients.

Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof

The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associ