38695-34-0

Usage

Uses

Used in Pharmaceutical Industry:
(E)-4-(2-(4-Fluorophenyl)ethenyl)benzenamine, N,N-dimethyl is used as a building block for the development of new pharmaceuticals due to its ability to participate in a wide range of chemical reactions. This makes it a valuable tool in the creation of novel drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (E)-4-(2-(4-Fluorophenyl)ethenyl)benzenamine, N,N-dimethyl is utilized as a key component in the synthesis of various agrochemicals. Its chemical properties allow for the development of new compounds that can be used in the agricultural sector for pest control, crop protection, and other related applications.
Used in Material Science:
(E)-4-(2-(4-Fluorophenyl)ethenyl)benzenamine, N,N-dimethyl also finds application in the field of material science. It serves as a versatile building block for the preparation of new materials with specific properties, such as improved stability, reactivity, or other desired characteristics.
Used in Chemical Research:
(E)-4-(2-(4-Fluorophenyl)ethenyl)benzenamine, N,N-dimethyl is also used in chemical research as a model or reference molecule for studying various reaction mechanisms, understanding the effects of structural modifications on chemical and physical properties, and exploring new synthetic routes for the development of complex organic molecules.
Used in Medicinal Chemistry and Pharmacology:
Due to its potential biological activity, (E)-4-(2-(4-Fluorophenyl)ethenyl)benzenamine, N,N-dimethyl may be of interest for further research in medicinal chemistry and pharmacology. It could serve as a starting point for the design and synthesis of new bioactive molecules with potential applications in drug discovery and development.

InChI:InChI=1/C16H16FN/c1-18(2)16-11-7-14(8-12-16)4-3-13-5-9-15(17)10-6-13/h3-12H,1-2H3/b4-3+

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 405-50-5 p-Fluorophenylacetic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 405-99-2 para-fluorostyrene 
• 93296-10-7 (4-(dimethylamino)phenyl)zinc(II) chloride 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 85609-00-3 (E/Z)-2-chloro-1-<4-(N,N-dimethylamino)phenyl>ethene 
• 85608-98-6 (E)-β-bromo-4-(N,N-dimethylamino)styrene 
• 80395-14-8 4-fluorobenzylphosphonic acid 
• 459-46-1 4-Fluorobenzyl bromide 
• 63909-58-0 diethyl (4-fluorobenzyl)phosphonate 
• 34904-03-5 4-(N,N-dimethylamino)benzyltriphenylphosphonium iodide 

Downstream Products

• 64583-45-5 {4-[2-(4-Fluoro-phenyl)-ethyl]-phenyl}-dimethyl-amine 
• 87287-00-1 1-Adamant-1-yl-2-(p-dimethylaminophenyl)-1-(p-fluorphenyl)-ethan 
• 87287-01-2 1-Adamant-1-yl-1-(p-dimethylaminophenyl)-2-(p-fluorphenyl)-ethan 

Relevant academic research and scientific papers

An Interrupted Pummerer/Nickel-Catalysed Cross-Coupling Sequence

An interrupted Pummerer/nickel-catalysed cross-coupling strategy has been developed and used in the elaboration of styrenes. The operationally simple method can be carried out as a one-pot process, involves the direct formation of stable alkenyl sulfonium salt intermediates, utilises a commercially available sulfoxide, catalyst, and ligand, operates at ambient temperature, accommodates sp-, sp2-, and sp3-hybridised organozinc coupling partners, and delivers functionalised styrene products in high yields over two steps. An interrupted Pummerer/cyclisation approach has also been used to access carbo- and heterocyclic alkenyl sulfonium salts for cross-coupling.

STILBENE ANALOGS AND METHODS OF TREATING CANCER

Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.

Effects of substituent and solvent on the UV absorption energy of 4,4′-disubstituted stilbenes

Twenty five samples of 4,4′-disubstituted stilbene derivatives were synthesized, and their UV absorption max wavelengths were determined in over 10 kinds of solvents including cyclohexane, ether, chloroform, acetonitrile and ethanol, in which 242 experimental data were recorded. The effects of substituents and solvents on the energy of their UV absorption max wavelengths were discussed. The research results showed: the energy of UV absorption max wavelengths of 4,4′-disubstituted stilbenes was mainly affected by their intramolecular structure (substituent effect) in a given solvent, that is, the energy is dominated by both of excited-state substituent parameter σ CC ex and polar substituent constant σ p. While their energy was dominated by the substituent effect and solvent effect in different kinds of solvents. An equation quantifying the energy of UV absorption max wavelengths of 4,4′-disubstituted stilbenes was developed. In addition, it is found that the n-octanol/water partition coefficient (logP) is more effective than the solvatochromic dye (E T(30)) in scaling the solvent effect. The equation employed the parameter logP has a better correlation and more specific physical meaning. Further, the energies of UV absorption max wavelengths of some reported compounds were predicted by the obtained equation, which are in agreement with their experimental values.

Radical fluoroarylation in radiochemical synthesis

In this study, we report on the radical [18F]fluoroarylation of different olefins using 4-[18F]fluorobenzenediazonium ions to provide a new route to radiopharmaceuticals containing a deactivated, 4-[18F]fluoro substituted

Stilbene derivatives and their use for binding and imaging amyloid plaques

This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting t

Electronic Structure and Free-Energy Relationships for Some 4'-Substituted 4-Dimethylamino trans-Stilbenes by U.V. Photoelectron Spectroscopy

A series of 4'-substituted 4-dimethylamino trans-stilbenes 1-5 was investigated by UPS, in connection with conjugated donor-acceptor substituted double bond photochemistry.The measured and assigned spectra indicate a high sensitivity, depending on the changed electronic structure by 4'-substituents of compounds 1-5.Correlation of ionization energies in LFE-relationship with Hammett's ?p-values and other ground state data was proved, demonstrating UPS a powerful tool for substituent effect studies in conjugated double bond systems.