38695-73-7

Usage

InChI:InChI=1/C11H8O2S/c12-11(13)9-6-7-14-10(9)8-4-2-1-3-5-8/h1-7H,(H,12,13)

Upstream product

• 98-80-6 phenylboronic acid 
• 38695-70-4 methyl 2-phenylthiophene-3-carboxylate 

Downstream Products

• 1047672-65-0 1-azabicyclo[2.2.2]oct-4-yl (2-phenyl-3-thienyl)carbamate hydrochloride 
• 1047672-62-7 (3R)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride 
• 1047672-60-5 (3S)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride 

Relevant academic research and scientific papers

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists

Herein, we describe the synthesis and pharmacological profiles of novel quinuclidinyl heteroarylcarbamate derivatives. Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagonist (LAMA) showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action in a rat model than tiotropium bromide.