38696-08-1

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 407-25-0 trifluoroacetic anhydride 
• 70887-29-5 4-methoxybenzyl iodide 
• 2966-50-9 silver trifluoroacetate 
• 794525-07-8 (4S,1'E,3'E)-(-1'-{[tert-butyl(dimethyl)silyl]oxy}-2'-methyl-1',3'-pentadienyl)-4-isopropyl-1,3-oxazolidin-2-one 

Downstream Products

• 1388792-38-8 (S)-2-(p-methoxybenzyl)-2,5-dihydrofuran 
• 1388792-78-6 C₁₂H₁₄O₂ 
• 1388793-16-5 (S)-3-(p-methoxybenzyl)-1-cycloheptene 
• 120349-79-3 (S)-tert-butyl 2-(4-methoxybenzyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 1388792-73-1 (S)-3-(p-methoxybenzyl)-1-cyclopentene 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant academic research and scientific papers

Stereoselective Alkylation of the Vinylketene Silyl N,O-Acetal and Its Application to the Synthesis of Mycocerosic Acid

Stereoselective alkylation of the vinylketene silyl N,O-acetal possessing a chiral auxiliary has been achieved by using activated alkyl halides including allyl iodides, benzyl iodides, and propargyl iodide with Ag(I) ion in the presence of BF3·

A general Pd-catalyzed α- And γ-benzylation of aldehydes for the formation of quaternary centers

A palladium-catalyzed benzylation of α-branched aldehydes has been developed using benzyl methyl carbonates. The method gives access to congested quaternary centers in the vicinity of one of the most sensitive carbonyl functionalities and displays unprecedented generality with respect to both coupling partners. Evidence for the direct involvement of a Pd-η3-benzyl intermediate is provided. Extension of this strategy to the γ-benzylation of α,β-unsaturated aldehydes is further demonstrated.

Palladium-catalyzed, asymmetric Mizoroki-Heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands

We report herein the first examples of asymmetric Mizoroki-Heck reactions using benzyl electrophiles. A new phosphoramidite was identified to be an effective chiral ligand in the palladium-catalyzed reaction. The reaction is compatible with polar functional groups and can be readily scaled up. Several cyclic olefins worked well as olefin components. Thirty-one examples are included.