38696-20-7

Usage

Uses

Used in Pharmaceutical Research:
5-Bromo-2-phenylpyrimidine is used as a key intermediate in the synthesis of various biologically active compounds. Its unique structure and properties contribute to the development of new drugs with potential pharmacological activities.
Used in Material Science Research:
In the field of material science, 5-Bromo-2-phenylpyrimidine is used as a starting material for the synthesis of functional materials. Its chemical properties allow for the creation of materials with specific characteristics for various applications.
Used in Agrochemical Development:
5-Bromo-2-phenylpyrimidine is also utilized as a precursor in the development of agrochemicals. Its role in the synthesis of pyrimidine-based compounds with potential pesticidal or herbicidal properties makes it a valuable component in agricultural research and product development.
Used in Synthesis of Pyrimidine-based Compounds:
5-Bromo-2-phenylpyrimidine is used as a starting material for the synthesis of a variety of pyrimidine-based compounds. These compounds have shown promise in exhibiting pharmacological activities, making it an essential component in the discovery and creation of novel therapeutic agents.

Upstream product

• 179260-95-8 5-bromo-2-phenyl-pyrimidine-4-carboxylic acid 
• 183438-24-6 5-bromo-2-iodopyrimidine 
• 98-80-6 phenylboronic acid 
• 32779-37-6 2,5-dibromopyrimidine 
• 100-47-0 benzonitrile 
• 2065-75-0 2-Bromo-malonaldehyde 
• 1670-14-0 benzamidine monohydrochloride 
• 114078-88-5 5-bromo-1,2,3-triazine 
• 618-39-3 benzamidin 

Downstream Products

• 66739-85-3 5-hydroxy-2-phenylpyrimidine 
• 545426-64-0 (2E)-3-(2-Phenyl-5-pyrimidinyl)-2-propenoic Acid Methyl Ester 
• 130161-46-5 2-phenylpyrimidine-5-carbaldehyde 
• 1119084-96-6 5-cyclopropyl-2-(2-phenylpyrimidin-5-ylamino)benzoic acid 
• 1217902-01-6 2-(2-phenylpyrimidin-5-yl)oxazole 
• 1217902-45-8 2-phenyl-5-(1-trityl-1H-imidazol-4-yl)pyrimidine 
• 1071323-12-0 1-(2-phenyl-pyrimidin-5-yl)-ethanone 
• 1217902-36-7 5-(1-benzyl-2-phenyl-1H-imidazol-5-yl)-2-phenylpyrimidine 
• 1217902-05-0 2-phenyl-5-(2-phenylpyrimidin-5-yl)oxazole 
• 1217902-51-6 2-phenyl-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)pyrimidine 
• 1217902-22-1 tert-butyl 2-(2-phenylpyrimidin-5-yl)thiazole-4-carboxylate 

Relevant academic research and scientific papers

Novel amide and imidazole compounds as potent hematopoietic prostaglandin D2 synthase inhibitors

In seeking novel and potent small molecule hematopoietic prostaglandin D2 synthase (H-PGDS) inhibitors as potential therapies for PGD2-mediated diseases and conditions, we explored a series comprising multiple aryl/heteroaryl rings attached in a linear arrangement. Each compound incorporates an amide or imidazole “linker” between the pyrimidine or pyridine “core” ring and the “tail” ring system. We synthesized and screened twenty analogs by fluorescence polarization binding assay, thermal shift assay, glutathione S-transferase inhibition assay, and a cell-based assay measuring suppression of LPS-induced PGD2 stimulation. Amide analogs show ten-fold greater shift in the thermal shift assay in the presence of glutathione (GSH) versus the same assay run in the absence of GSH. The imidazole analogs did not produce a significant change in thermal shift between the two assay conditions, suggesting a possible stabilization effect of the amide linker in the synthase-GSH-inhibitor complex. Imidazole analog 23, (KMN-010034) demonstrates superior potency across the in vitro assays and good in vitro metabolic stability in both human and guinea pig liver microsomes.

Material for organic light-emitting device and organic light-emitting device thereof

The invention provides a material for an organic light-emitting device and the organic light-emitting device thereof, and relates to the technical field of organic photoelectric materials. According to the invention, C site substitution of carbazole is carried out with an aryl-substituted pyrimidinyl, and N site substitution of carbazole is carried out with a specific heteroaryl; finally, the dendritic-structure material for the organic light-emitting device is formed. The glass transition temperature is high, the thermal stability is good, the film-forming property is good, the refractive index is high, the water and oxygen corrosion resistance is realized, and the synthesis is simple; the material can be applied to the organic light-emitting device as a covering layer, can effectively solve the problems of low refractive index, poor thermal stability, poor water and oxygen resistance stability, low luminous efficiency and short service life of the organic light-emitting device, and the organic light-emitting device has the advantages of high luminous efficiency and long service life.

Preparation method of 5-bromo-2-substituted pyrimidine compound

The invention discloses a preparation method of a 5-bromo-2-substituted pyrimidine compound. The 5-bromo-2-substituted pyrimidine compound is obtained through a one-step reaction by using 2-bromomalonaldehyde and an amidine compound as raw materials. The

ORGANOMETALLIC IRIDIUM COMPLEX, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE

PROBLEM TO BE SOLVED: To provide a long-lifetime organometallic iridium complex exhibiting yellow light emission with high emission efficiency as a novel substance. SOLUTION: The organometallic iridium complex includes a ligand in which an unsubstituted phenyl group is bonded to each of the 2-position and the 5-position of pyrimidine. The organometallic iridium complex has a structure represented by General Formula (G1). COPYRIGHT: (C)2016,JPO&INPIT

A arylpyrimidines and its derivatives preparation method (by machine translation)

This invention has offered a kind of arylpyrimidines and process for preparing derivatives thereof, comprising the following steps: S1) shown in the formula (II) 2 the iminium salts dial two substituted propionic [...], shown in formula (III) compound with a nitrile group of alkaline catalyst 1st reaction in the organic solvent, get mixed solution; S2) in the mixed solution is added with ammonium salt and 2nd alkaline catalyst, for the reaction, formula (I) shown in the arylpyrimidines and its derivatives. Compared with the prior art, this invention is in the presence of the alkaline catalyst, 2 the iminium salts dial two substituted propionic [...], of nitrile compounds and ammonium salt [3+2 + 1] ternary cyclization reaction to construct a pyrimidine ring, in order to get arylpyrimidines and its derivatives, this method does not use the noble metal catalyst, line is simple, low cost, high controllability of the process, easy industrialization, reduces the waste of relatively high yield and emissions. (by machine translation)

Organometallic Iridium Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device

To provide a long-lifetime organometallic iridium complex exhibiting yellow light emission with high emission efficiency as a novel substance. The organometallic iridium complex includes a ligand in which an unsubstituted phenyl group is bonded to each of

HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS

ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Inverse electron demand diels-alder reactions of 1,2,3-triazines: Pronounced substituent effects on reactivity and cycloaddition scope

A systematic study of the inverse electron demand Diels-Alder reactions of 1,2,3-triazines is disclosed, including an examination of the impact of a C5 substituent. Such substituents were found to exhibit a remarkable impact on the cycloaddition reactivity of the 1,2,3-triazine without altering, and perhaps even enhancing, the intrinsic cycloaddition regioselectivity. The study revealed not only that the reactivity may be predictably modulated by a C5 substituent (R = CO2Me > Ph > H) but also that the impact is of a magnitude to convert 1,2,3-triazine (1) and its modest cycloaddition scope into a heterocyclic azadiene system with a reaction scope that portends extensive synthetic utility, expanding the range of participating dienophiles. Significantly, the studies define a now powerful additional heterocyclic azadiene, complementary to the isomeric 1,2,4-triazines and 1,3,5-triazines, capable of dependable participation in inverse electron demand Diels-Alder reactions, extending the number of complementary heterocyclic ring systems accessible with implementation of the methodology.

MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES

Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D2 mediated diseases and conditions that may be modulated by the inhibition of hematopoietic prostaglandin D synthase (H-PGDS).

AZABIPHENYLAMINOBENZOIC ACID DERIVATIVES AS DHODH INHIBITORS

New azabiphenylaminobenzoic acid derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the dehydroorotate dihydrogenase (DHODH)