387-48-4

Usage

Uses

Used in Pharmaceutical Research and Development:
3-Fluoro-2-iodobenzoic acid is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure with a fluorine and iodine atom allows for the creation of new molecules with potential therapeutic applications.
Used in Chemical Synthesis:
3-Fluoro-2-iodobenzoic acid is used as a building block in the synthesis of other specific chemicals. Its presence in the molecular structure can influence the properties and reactivity of the resulting compounds, making it a valuable component in the development of new materials and substances.
Used in Research Laboratories:
3-Fluoro-2-iodobenzoic acid is used as a research tool in academic and industrial laboratories. Its unique properties and reactivity make it an interesting subject for studies in organic chemistry, materials science, and related fields.

InChI:InChI=1/C7H4FIO2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,(H,10,11)

Upstream product

• 825-22-9 3-fluoroanthranilic acid 
• 455-38-9 3-fluorobenzoic acid 
• 5398-69-6 2-iodo-3-nitrobenzoic acid 
• 85600-30-2 3-amino-2-iodo-benzoic acid 

Downstream Products

• 389-43-5 ethyl 3-fluoro-2-iodobenzoate 
• 1428865-42-2 C₁₄H₁₂FNO 
• 1428865-27-3 C₁₄H₁₄FNO 
• 1428865-15-9 C₁₅H₁₄FNO₂ 
• 1035262-57-7 ethyl 2-(3-fluoro-2-(3,3,3-triethoxyprop-1-ynyl)phenyl)acetate 
• 1035262-56-6 ethyl 2-(3-fluoro-2-iodophenyl)acetate 
• 1293286-24-4 3-fluoro-2-(1H-1,2,3-triazol-1-yl)benzoic acid 
• 1214622-53-3 3-fluoro-2-(1H-pyrazol-1-yl)benzoic acid 
• 1040861-05-9 3-fluoro-2-iodobenzoyl chloride 
• 393-78-2 3-fluoro-2-iodo-benzoic acid methyl ester 

Relevant academic research and scientific papers

IrIII-Catalyzed Selective ortho-Monoiodination of Benzoic Acids with Unbiased C?H Bonds

An iridium-catalyzed selective ortho-monoiodination of benzoic acids with two equivalent C?H bonds is presented. A wide range of electron-rich and electron-poor substrates undergo the reaction under mild conditions, with >20:1 mono/di selectivity. Importantly, the C?H iodination occurs selectively ortho to the carboxylic acid moiety in substrates bearing competing coordinating directing groups. The reaction is performed at room temperature and no inert atmosphere or exclusion of moisture is required. Mechanistic investigations revealed a substrate-dependent reversible C?H activation/protodemetalation step, a substrate-dependent turnover-limiting step, and the crucial role of the AgI additive in the deactivation of the iodination product towards further reaction.

Base- and Additive-Free Ir-Catalyzed ortho-Iodination of Benzoic Acids: Scope and Mechanistic Investigations

A protocol for the C-H activation/iodination of benzoic acids catalyzed by a simple iridium complex has been developed. The method described in this paper allows the ortho-selective iodination of a variety of benzoic acids under extraordinarily mild conditions in the absence of any additive or base in 1,1,1,3,3,3-hexafluoroisopropanol as the solvent. The iridium catalyst used tolerates air and moisture, and selectively gives ortho-iodobenzoic acids with high conversions. Mechanistic investigations revealed that an Ir(III)/Ir(V) catalytic cycle operates, and that the unique properties of HFIP enables the C-H iodination using the carboxylic moiety as a directing group.

NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) and Formula (II) are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula(I) and Formula (II) have the following structures, where the definitions of the variables are provided herein.

Condensed pyrazole derivatives, process for producing the same and use thereof

Novel pharmaceutical compositions for inhibiting Th2-selective immune response and pharmaceutical compositions for inhibiting cyclooxygenase comprising condensed pyrazole derivatives represented by the general formula (I): or salts thereof.