387-48-4

Basic information

• Product Name: 3-FLUORO-2-IODOBENZOIC ACID
• Synonyms: BUTTPARK 122\01-05;3-FLUORO-2-IODOBENZOIC ACID;2-IODO-3-FLUOROBENZOIC ACID;3-Fluoro-2-Iodobenzoic Acid 2-Iodo-3-Fluorobenzoic Acid;3-Fluoro-2-iodobenzoic;3-FLUORO-2-IODOBENZOIC ACID,98%
• CAS NO: 387-48-4
• Molecular Formula: C₇H₄FIO₂
• Molecular Weight: 266.01
• Product Categories: Fluorine series
• Mol File: 387-48-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 152-153 °C
• Boiling Point: 313.97 °C at 760 mmHg
• Flash Point: 143.684 °C
• Appearance: /
• Density: 2.074 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.52±0.10(Predicted)
• CAS DataBase Reference: 3-FLUORO-2-IODOBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-2-IODOBENZOIC ACID(387-48-4)
• EPA Substance Registry System: 3-FLUORO-2-IODOBENZOIC ACID(387-48-4)

Safety Data

• Hazardous Substances Data: 387-48-4(Hazardous Substances Data)

Usage

General Description

3-Fluoro-2-iodobenzoic acid is a specialist chemical compound with the scientific formula C7H4FIO2. It is known by the systematic IUPAC name of 3-fluoro-2-iodobenzoic acid and has the molecular weight of 292.01 g/mol. Belonging to the organic compound family, it is a derivative of benzoic acid with a fluorine atom and an iodine atom attached to the benzene ring. It is commonly used in the synthesis of other specific chemicals, especially in pharmaceutical research and development processes. However, like many chemicals, it is advised to handle this compound with care as it can cause skin and eye irritation, and may also cause respiratory irritation if inhaled.

InChI:InChI=1/C7H4FIO2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,(H,10,11)

Upstream product

• 455-38-9 3-fluorobenzoic acid 
• 825-22-9 3-fluoroanthranilic acid 
• 5398-69-6 2-iodo-3-nitrobenzoic acid 
• 85600-30-2 3-amino-2-iodo-benzoic acid 

Downstream Products

• 389-43-5 ethyl 3-fluoro-2-iodobenzoate 
• 1035262-57-7 ethyl 2-(3-fluoro-2-(3,3,3-triethoxyprop-1-ynyl)phenyl)acetate 
• 1035262-56-6 ethyl 2-(3-fluoro-2-iodophenyl)acetate 
• 1040861-05-9 3-fluoro-2-iodobenzoyl chloride 
• 393-78-2 3-fluoro-2-iodo-benzoic acid methyl ester 
• 1214622-53-3 3-fluoro-2-(1H-pyrazol-1-yl)benzoic acid 
• 1293286-24-4 3-fluoro-2-(1H-1,2,3-triazol-1-yl)benzoic acid 
• 1428865-15-9 C₁₅H₁₄FNO₂ 
• 1428865-27-3 C₁₄H₁₄FNO 
• 1428865-42-2 C₁₄H₁₂FNO 

Relevant articles and documents

IrIII-Catalyzed Selective ortho-Monoiodination of Benzoic Acids with Unbiased C?H Bonds

An iridium-catalyzed selective ortho-monoiodination of benzoic acids with two equivalent C?H bonds is presented. A wide range of electron-rich and electron-poor substrates undergo the reaction under mild conditions, with >20:1 mono/di selectivity. Importantly, the C?H iodination occurs selectively ortho to the carboxylic acid moiety in substrates bearing competing coordinating directing groups. The reaction is performed at room temperature and no inert atmosphere or exclusion of moisture is required. Mechanistic investigations revealed a substrate-dependent reversible C?H activation/protodemetalation step, a substrate-dependent turnover-limiting step, and the crucial role of the AgI additive in the deactivation of the iodination product towards further reaction.

NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) and Formula (II) are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula(I) and Formula (II) have the following structures, where the definitions of the variables are provided herein.