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3870-07-3

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3870-07-3 Usage

Glucocorticoid

Triamcinolone acetonide acetate ,as a glucocorticoid drug, is white or almost white crystalline powder, which is odorless and bitter taste. It is slightly soluble in water, ethanol and acetone and soluble in chloroform. It is currently a long-acting glucocorticoid drug widely used in our dermatology clinical application, also known as Block technique, triamcinolone acetonide, Connor music cream and Conor-A. It belongs to adrenocortical hormones drugs and s from the triamcinolone. The effects of glucocorticoid triamcinolone acetonide acetate, similar to the role of triamcinolone, includes anti-inflammatory, anti-allergic, anti-itching and contracting capillaries. The role of its water and sodium retention is weak, while the anti-Inflammatory and anti-allergic effects are stronger and more durable than hydrocortisone (10 to 30 times) and prednisone. Its application in aerosol inhalation treatment of bronchial asthma is strong and lasting. The local curative effect is better than the triamcinolone. Oral is easy to absorb. Oral administration is 5mg and the bioavailability is about 23%. Its plasma concentration reaches the peak value of 105mg/ml after 1 hour, with a half-life of 2 hours. The intramuscular injection has a slow absorption process, and its effects begin within a few hours, reach to the maximum after 1 or 2 days and last about 2 or 3 weeks; the intradermal and intra-articular injection of this drug has slow-absorption and lasting-effects and the general effects of one injection can be maintained for 1 to 2 weeks or more. This drug binds with plasma albumin less, metabolizes into non-active metabolites in the liver, kidney and tissue and finally is excreted by the kidneys. Local injection can also have a lasting effect, as well as ointment topical. Clinically, the triamcinolone acetonide is mainly used for the treatment of various skin diseases such as atopic dermatitis, contact dermatitis, seborrheic dermatitis, neurodermatitis, eczema, psoriasis, psoriasis, lichen planus and other skin diseases and skin pruritus, as well as many infectious diseases including bronchial asthma, rheumatoid arthritis, acute sprain, chronic low back pain, scapulohumeral periarthritis, tenosynovitis, eye inflammation, oral mucosal hyperemia, erosions, ulcers, granulomatous cheilitis and oral mucosa. It can also be used in the local injection of some small area damages like keloid, cystic acne, discoid lupus erythematosus and alopecia areata. Triamcinolone acetonide acetate nasal spray can be used for the prevention and treatment of perennial and seasonal allergic rhinitis and vasomotor rhinitis. Its intra-articular injection can eliminate inflammation and relieve the pain, swelling or stiffness felling.

Uses

Different sources of media describe the Uses of 3870-07-3 differently. You can refer to the following data:
1. Triamcinolone acetonide acetate can be used for eczema and dermatitis and is currently a long-acting glucocorticoid drug widely applied in the dermatology clinical application of China. It derives from triamcinolone and plays a similar role.
2. Triamcinolone acetonide 21-acetate is derivative of Triamcinolone Acetonide, a glucocorticoid, antiasthmatic (inhalant).It also can be used for eczema and dermatitis and is currently a long-acting glucocorticoid drug widely applied in the dermatology clinical application of China.

Chemical Properties

White Solid

Check Digit Verification of cas no

The CAS Registry Mumber 3870-07-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,7 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3870-07:
(6*3)+(5*8)+(4*7)+(3*0)+(2*0)+(1*7)=93
93 % 10 = 3
So 3870-07-3 is a valid CAS Registry Number.

3870-07-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 21-(Acetyloxy) Triamcinolone Acetonide

1.2 Other means of identification

Product number -
Other names Triamcinolone acetonide 21-acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3870-07-3 SDS

3870-07-3Downstream Products

3870-07-3Relevant articles and documents

Triamcinolone acetonide acetate preparation method

-

, (2018/03/24)

The invention provides a full-novel synthesizing route for preparing triamcinolone acetonide acetate. According to the full-novel synthetic route, utilized raw materials have lower cost and more easiness in obtaining. The synthetic route comprises the steps of hydroxylating reaction raw materials and protecting, then selectively oxidizing five-membered ring double bonds, removing a protecting group, then protecting oxidized di-hydroxyl, then epoxidizing six-membered ring double bonds, performing open-ring fluorination and esterfying hydroxyl to obtain a triamcinolone acetonide product. A reaction process has easiness in operation, yields of all the steps are higher, obtained products have higher purities, byproduct generation is effectively avoided, production cost is reduced, and industrial production is facilitated.

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