38710-83-7

Upstream product

• 50594-78-0 5-fluoro-2-nitrobenzonitrile 
• 108-95-2 phenol 
• 34662-31-2 3-chloro-6-nitrobenzonitrile 

Downstream Products

• 1269408-70-9 N₁-{(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}-3-(2-thienyl)-L-alaninamide hydrochloride 
• 1269407-64-8 1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}amino)-2-oxo-1-(2-thienylmethyl)ethyl]carbamate 
• 1269407-63-7 2-[(3S)-3-amino-1-pyrrolidinyl]-5-(phenyloxy)benzonitrile hydrochloride 
• 1269407-62-6 1,1-dimethylethyl {(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}carbamate 
• 1269407-61-5 2-bromo-5-phenoxybenzonitrile 
• 38710-93-9 2-amino-5-phenoxybenzonitrile 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE

Provided herein, inter alia, are compounds and methods for modulating Bruton's Tyrosine Kinase.

CATHEPSIN C INHIBITORS

Disclosed are 3-aminopyrrolidines of Formula (I) having pharmacological activity, pharmaceutical compositions containing them, and methods for the treatment of diseases mediated by the cathepsin C enzyme such as chronic obstructive pulmonary disease.

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may