387338-37-6

Basic information

• Product Name: 4-nitrophenethyl tert-butylphosphonate
• Synonyms: 4-nitrophenethyl tert-butylphosphonate
• CAS NO: 387338-37-6
• Molecular Weight: 287.252
• Mol File: 387338-37-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-nitrophenethyl tert-butylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitrophenethyl tert-butylphosphonate(387338-37-6)
• EPA Substance Registry System: 4-nitrophenethyl tert-butylphosphonate(387338-37-6)

Safety Data

• Hazardous Substances Data: 387338-37-6(Hazardous Substances Data)

Upstream product

• 4707-95-3 tert-butyl phosphinyl dichloride 
• 100-27-6 2-(4-nitrophenyl)ethanol 

Relevant articles and documents

Pivalase catalytic antibodies: Towards abzymatic activation of prodrugs

Screening of monoclonal-an-tibody libraries generated against the tert-butyl phosphonate hapten 2 and the chloromethyl phosphonate hapten 3 with pivaloyloxymethyl-umbelliferone 1 as a fluorogenic substrate led to the isolation of eleven catalytic antibodies with rate accelerations around kcat/kuncat=103. The antibodies are not inhibited by the product and accept different acyloxymethyl derivatives of acidic phenols as substrates. The highest activity was found for the bulky, chemically less-reactive pivaloyloxymethyl group; there is no activity with acetoxymethyl or acetyl esters. This difference might reflect the preference of the immune system for hydrophobic interactions in binding and catalysis. Pivalase catalytic antibodies might be useful for activating orally available pivaloyloxymethyl prodrugs.