387353-97-1Relevant academic research and scientific papers
Synthesis and reactions of silylated and stannylated 1,2-azoles
Calle,Cuadrado,Gonzalez-Nogal,Valero
, p. 1949 - 1958 (2007/10/03)
Silicon or tin 4-metalated pyrazoles and isoxazoles are synthesized by silyl- or stannylcupration from 4-haloazoles. On the other hand, 5-metalated pyrazoles are prepared by reaction of 5-un-substituted pyrazoles with LDA and subsequent treatment with chlorosilanes and chlorostannanes. Furthermore, starting from 5-unsubstituted 4-halopyrazoles and applying both methodologies, 4,5-dimetalated pyrazoles bearing silyl groups different from trimethylsilyl or tributylstannyl groups are obtained. Some regioselective ipso-substitutions are also studied.
