3729-90-6

Basic information

• Product Name: 1,5-DIPHENYL-3-METHYL-1H-PYRAZOLE
• Synonyms: 1,5-DIPHENYL-3-METHYL-1H-PYRAZOLE;1,5-DIPHENYL-3-METHYLPYRAZOLE;3-METHYL-1,5-DIPHENYL-1H-PYRAZOLE
• CAS NO: 3729-90-6
• Molecular Formula: C₁₆H₁₄N₂
• Molecular Weight: 234.3
• Product Categories: Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;pharmacetical
• Mol File: 3729-90-6.mol
• Article Data: 48

Chemical Properties

• Melting Point: 63 °C
• Boiling Point: 380.4°Cat760mmHg
• Flash Point: 183.8°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 1.2E-05mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 0.61±0.10(Predicted)
• CAS DataBase Reference: 1,5-DIPHENYL-3-METHYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-DIPHENYL-3-METHYL-1H-PYRAZOLE(3729-90-6)
• EPA Substance Registry System: 1,5-DIPHENYL-3-METHYL-1H-PYRAZOLE(3729-90-6)

Safety Data

• Hazardous Substances Data: 3729-90-6(Hazardous Substances Data)

Usage

Uses

1,5-Diphenyl-3-methylpyrazole is a useful reagent for the preparation of selanylpyrazoles.

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 1973, 1988 DOI: 10.1021/jo00244a024

InChI:InChI=1/C16H14N2/c1-13-12-16(14-8-4-2-5-9-14)18(17-13)15-10-6-3-7-11-15/h2-12H,1H3

Upstream product

• 100-63-0 phenylhydrazine 
• 1817-57-8 4-phenyl-3-butyne-2-one 
• 61210-87-5 [((E)-4-phenylbut-3-en-2-ylidene)amino]hydroxide 
• 59-88-1 phenylhydrazine hydrochloride 
• 64-17-5 ethanol 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 127-09-3 sodium acetate 
• 108086-92-6 3-benzoyl-4-(methylamino)-3-penten-2-one 
• 70769-77-6 (Z)-4-Ethylsulfanyl-4-phenyl-but-3-en-2-one 
• 22921-89-7 1-(4-phenylbut-3-en-2-ylidene)-2-phenylhydrazone 
• 2515-46-0 3-methyl-1,5-diphenyl-4,5-dihydro-1H-pyrazole 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 

Downstream Products

• 873913-84-9 4-iodo-3-methyl-1,5-diphenyl-1H-pyrazole 
• 1428979-43-4 3-methyl-1,5-diphenyl-4-(phenylethynyl)-1H-pyrazole 
• 1428979-45-6 N-tert-butyl-3-methyl-1,5-diphenyl-1H-pyrazole-4-carboxamide 
• 41461-99-8 3-methyl-1,5-diphenyl-1H-pyrazole-4-carbaldehyde 
• 94206-50-5 4-bromo-3-methyl-1,5-diphenyl-1H-pyrazole 
• 53359-46-9 3,4-dimethyl-1,5-diphenyl-1H-pyrazole 
• 263328-03-6 3-methyl-1,5-diphenyl-1H-pyrazole-4-carboxylic acid methylamide 
• 40030-35-1 3-methyl-1,5-diphenylpyrazole-4-carboxylic acid 
• 873913-96-3 dimethyl-[3-(3-methyl-1,5-diphenyl-pyrazol-4-yl)-prop-2-ynyl]-amine 
• 101728-02-3 3-methyl-4-nitro-1,5-bis-(4-nitro-phenyl)-1H-pyrazole 
• 13599-22-9 1,5-diphenylpyrazole-3-carboxylic acid 
• 59340-39-5 4-chloro-3-methyl-1,5-diphenyl-1H-pyrazole 
• 2515-46-0 3-methyl-1,5-diphenyl-4,5-dihydro-1H-pyrazole 

Relevant articles and documents

SO2F2 mediated transformation of pyrazolones into pyrazolyl fluorosulfates

The construction of a class of novel N-heterocyclic molecules containing both pyrazole and fluorosulfate functionalities was achieved through the reactions of pyrazolones with SO2F2 in good to excellent yields. The fluorosulfate moieties were utilized as versatile building blocks in the Suzuki coupling reaction and SuFEx click chemistry.

Synthesis of 1: H -indazoles by an electrochemical radical Csp2-H/N-H cyclization of arylhydrazones

The development of efficient and sustainable C-N bond-forming reactions to N-heterocyclic frameworks has been a long-standing interest in organic synthesis. In this work, we develop an electrochemical radical Csp2-H/N-H cyclization of arylhydrazones to 1H-indazoles. The electrochemical anodic oxidation approach was adopted to synthesize a variety of 1H-indazole derivatives in moderate to good yields. HFIP was not only employed as a solvent or the proton donor, but also can promote the formation of N free radicals. This synthetic methodology is operationally simple, and less expensive electrodes would be suitable for this chemistry. This journal is

Copper-Promoted Coupling of Propiophenones and Arylhydrazines for the Synthesis of 1,3-Diarylpyrazoles

Synthesis of 1,3-diarylpyrazoles from commercial substrates and/or simple transformations is still underrated. In this report, we have developed a method for copper-promoted coupling of propiophenones and arylhydrazines. The reactions afforded substituted pyrazoles in the presence of TEMPO oxidant, acetic acid additive, and DMF solvent. A number of functionalities were compatible with reaction conditions, including halogens, methoxy, trifluoromethyl, and nitro groups. An indazole could be obtained if an electron-poor propiophenone was used.