387384-49-8Relevant academic research and scientific papers
Synthesis, biological evaluation and molecular dynamic simulations of novel Benzofuran-tetrazole derivatives as potential agents against Alzheimer's disease
Kushwaha, Pragati,Fatima, Soobiya,Upadhyay, Akanksha,Gupta, Sampa,Bhagwati, Sudha,Baghel, Tanvi,Siddiqi,Nazir, Aamir,Sashidhara, Koneni V.
, p. 66 - 72 (2018/11/23)
A series of novel Benzofuran-tetrazole derivatives were successfully synthesised by integrating multicomponent Ugi-azide reaction with the molecular hybridization approach. Interestingly, a number of synthesized derivatives (5c, 5d, 5i, 5l, 5q and 5s) exhibited significant reduction of aggregation of “human” amyloid beta peptide, expressing on transgenic Caenorhabditis elegans (C. elegans) strain CL4176. Further, in silico docking results have evidenced the exquisite interaction of active compounds with the help of TcAChE–E2020 complex. These findings underscore the potential of these hybrids as lead molecules against Alzheimers's disease.
A convenient synthesis of 2(2-benzo[b]furo) indoles and benzofuropyrazoles
Goudarshivannanavar,Jayadevappa,Mahadevan
experimental part, p. 1419 - 1423 (2010/02/28)
A short synthesis of benzo[b]furo indolyls 3a-g from 2-acetylbenzofuran 1 in two steps and corresponding pyrazoles 4a-g is described. An interesting scale-up procedure for the synthesis of 2-acetylbenzofuran is also been reported. Similarly 2-acetylbenzofurohydrazones 2a-g is prepared from 2-acetyl benzofuran and with various phenylhydrazine hydrochlorides in presence of CH3COONa/EtOH at RT in excellent yield (90-95%). These 2-acetyl benzofurohydrazones 2a-g are subjected to Fiseher indole cyelisation in presence of ZnCl2 in acetonitrile as solvent to get 2(2-benzo[b]furo)indolcs 3a-g in good yield.
