38740-12-4Relevant academic research and scientific papers
HETEROADAMANTANES AND THEIR DERIVATIVES 11. SYNTHESIS OF 3,6-DIAZAHOMOADAMANTAN-9-ONE AND ITS DERIVATIVES WITH SUBSTITUENTS IN THE ANGULAR POSITIONS
Kuznetsov, A. I.,Vladimirova, I. A.,Basargin, E. B.,Ba, M. Kh.,Moskovkin, A. S.,Botnikov, M. Ya.
, p. 572 - 578 (2007/10/02)
The condensation of ketones with tetramethylenediethylenediamine led to the isolation of 3,6-diazahomoadamantan-9-one and its derivatives with substituents in the angular positions; their structure was confirmed by the data of the IR, PMR, and mass spectr
A Study on the Double Mannich Reaction with 1,3-Diphenylacetone
Afsah, E. M.,Hammouda, M.,Abou-Elzahab, M. M.
, p. 581 - 586 (2007/10/02)
Double Mannich reaction of the title compound 1 with morpholine acetate in ethanol gave the symmetrical bis-base 2, whereas such reaction in acetic acid afforded the vinyl-ketonic base 3.Reactions of 3 with morpholine, piperidine, thiophenol and dimethyl phosphite were investigated.Mannich reaction of 2 with primary amines gave di-basically substituted γ-piperidones 6a-b.Compound 1 reacts with ethylenediamine and formaldehyde to give the diazatricyclic system 7. - Keywords: Symmetrical bis-Mannich bases; Bis(morpholinomethyl-γ-piperidones; 3,6-Diazatricyclo3,8>undecanone; Nitrogen heterocycles
