38749-93-8Relevant academic research and scientific papers
Synthesis of highly functionalized pyridines for planar polymers. Maximized π-conjugation in electron deficient macromolecules
Yao, Yuxing,Lamba, Jaydeep J. S.,Tour, James M.
, p. 2805 - 2810 (1998)
Synthetic routes to planar polypyridines are described. Two pyridine monomers for the step growth polymerization are prepared starting from 2,5- 1utidine via 2,5-dibromopyridine-3,6-dicarboxylic acid as the common intermediate, The dicarboxylic acid serve
Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions
Benz, Sebastian,N?tzli, Sarah,Siegel, Jay S.,Eberli, Daniel,Jessen, Henning J.
, p. 10171 - 10182 (2014/01/17)
In tissue engineering, survival of larger constructs remains challenging due to limited supply of oxygen caused by a lack of early vascularization. Controlled release of oxygen from small organic molecules represents a possible strategy to prevent cell death under anoxic conditions. A comprehensive study of methylated pyridone-derived endoperoxides has led to the development of water-soluble molecules that undergo retro-Diels-Alder reactions in aqueous environment releasing oxygen in high yield and with half-lives of up to 13 h. These molecules in combination with vitamin C as singlet oxygen quencher significantly improved survival of 3T3 fibroblasts and rat smooth muscle cells challenged with oxygen-depleted conditions.
