53428-02-7Relevant academic research and scientific papers
A catalytic oxidation fragrant boron class compound preparing phenol method (by machine translation)
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Paragraph 0073; 0083; 0084, (2017/08/08)
The invention discloses a method for catalytic oxidation of phenolic compounds fragrant boron class compound synthesis method, the flux in the solvent in the aqueous solution, under the action of alkali, adding hydrazine hydrate or acid hydrazides catalyst, catalytic oxidation fragrant boron class compound directly for the preparation of phenolic compound. The invention of the method of preparation of the phenol compound, the catalyst is a cheap hydrazine hydrate or hydrazine compound, the oxidizing agent is atmospheric pressure of air or oxygen, the reaction does not need good and activeness metal catalyst, is extensive and stable substrate, substrate-sensitive functional group compatibility good and wide range of application. In the optimized under the reaction conditions, the yield of the target product separation up to 99%. (by machine translation)
TETRAZOLINONE COMPOUND AND USE THEREFOR
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Paragraph 0663; 0664, (2016/07/05)
A tetrazolinone compound represented by formula (1): wherein R1 and R2 are the same or different and represent a hydrogen atom, etc.; R3 represents a C1-C6 alkyl group, etc.; R4, R5, and R6 are the same or different and represent a hydrogen atom, etc.; A represents a C6-C10 aryl group optionally having one or more atoms or groups selected from Group P1, etc.; Q represents the following group Q1; and X represents an oxygen atom, has excellent control activity against pests.
Tetrazolinone compound, and use therefor
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Paragraph 1059; 1060; 1061; 1062, (2016/10/08)
A tetrazolinone compound represented by formula (1) (in the formula, R1 and R2 are the same or different, and represent a hydrogen atom, or the like; R3 represents a C1-C6 alkyl group, or the like; R4, R5 and R6 are the same or different, and represent a hydrogen atom, or the like; A represents a C6-C10 aryl group, or the like, which may have one or more atoms or groups selected from group (P1); Q represents group (Q1), or the like; and X represents an oxygen atom, or the like). The tetrazolinone compound has an excellent pest-control effect.
Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions
Benz, Sebastian,N?tzli, Sarah,Siegel, Jay S.,Eberli, Daniel,Jessen, Henning J.
, p. 10171 - 10182 (2014/01/17)
In tissue engineering, survival of larger constructs remains challenging due to limited supply of oxygen caused by a lack of early vascularization. Controlled release of oxygen from small organic molecules represents a possible strategy to prevent cell death under anoxic conditions. A comprehensive study of methylated pyridone-derived endoperoxides has led to the development of water-soluble molecules that undergo retro-Diels-Alder reactions in aqueous environment releasing oxygen in high yield and with half-lives of up to 13 h. These molecules in combination with vitamin C as singlet oxygen quencher significantly improved survival of 3T3 fibroblasts and rat smooth muscle cells challenged with oxygen-depleted conditions.
OXADIAZOLIDINEDIONE COMPOUND
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Page/Page column 25, (2010/08/18)
A pharmaceutical agent having GPR40 receptor agonistic action, particularly a compound which is useful as an insulin secretagogue or an agent for preventing and/or treating diabetes mellitus. The present inventors have examined a compound having GPR40 receptor agonistic action, confirmed that an oxadiazolidinedione compound which has a substituent such as a benzyl group, etc. linked with a substituent such as a phenyl group, etc. through a linker at the 2-position of an oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof has an excellent GPR40 agonistic activity, and thus completed the invention. The oxadiazolidinedione compound has excellent insulin secretagogue action and anti-hyperglycemic action, and therefore can be used as an insulin secretagogue or an agent for preventing and/or treating diabetes mellitus.
