38752-37-3

Usage

Uses

Used in Cancer Prevention and Treatment Applications:
(2-ISOTHIOCYANATOETHYL)THIO]BENZENE is used as a cancer prevention and treatment agent for its ability to inhibit the growth of cancer cells and induce apoptosis in various types of cancer. It targets multiple cellular pathways involved in cancer development and progression, making it a promising candidate for cancer therapy.
Used in Anti-inflammatory and Antioxidant Applications:
(2-ISOTHIOCYANATOETHYL)THIO]BENZENE is used as an anti-inflammatory and antioxidant agent due to its potential therapeutic effects in a variety of conditions. Its ability to reduce inflammation and oxidative stress may contribute to the prevention and treatment of various diseases and disorders.
Used in Pharmaceutical Industry:
(2-ISOTHIOCYANATOETHYL)THIO]BENZENE is used in the pharmaceutical industry for the development of drugs and therapeutic agents targeting cancer, inflammation, and oxidative stress-related conditions. Its potential applications in this industry include the creation of novel cancer treatments, anti-inflammatory medications, and antioxidant supplements.
Used in Functional Food Industry:
(2-ISOTHIOCYANATOETHYL)THIO]BENZENE can be used in the functional food industry as a natural compound with potential health benefits. Its presence in certain vegetables, such as broccoli and watercress, may contribute to the development of functional foods with enhanced cancer prevention and treatment properties, as well as anti-inflammatory and antioxidant effects.

InChI:InChI=1/C9H9NS2/c11-8-10-6-7-12-9-4-2-1-3-5-9/h1-5H,6-7H2

Upstream product

• 463-71-8 thiophosgene 
• 34946-13-9 (2-aminoethyl) phenyl sulfide hydrochloride 
• 75-15-0 carbon disulfide 
• 106118-84-7 (2-azidoethyl)(phenyl)sulfane 
• 2014-75-7 2-(phenylthio)ethanamine 
• 96989-50-3 di-2-pyridyl thionocarbonate 

Downstream Products

• 1629871-56-2 3-[2-(phenylsulfanyl)ethyl]-2-thioxoimidazolidin-4-one 

Relevant academic research and scientific papers

1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity

Metallo-β-lactamases (MBLs) are important contributors of Gram-negative bacteria resistance to β-lactam antibiotics. MBLs are highly worrying because of their carbapenemase activity, their rapid spread in major human opportunistic pathogens while no clinically useful inhibitor is available yet. In this context, we are exploring the potential of compounds based on the 1,2,4-triazole-3-thione scaffold as an original ligand of the di-zinc active sites of MBLs, and diversely substituted at its positions 4 and 5. Here, we present a new series of compounds substituted at the 4-position by a thioether-containing alkyl chain with a carboxylic and/or an aryl group at its extremity. Several compounds showed broad-spectrum inhibition with Ki values in the μM to sub-μM range against VIM-type enzymes, NDM-1 and IMP-1. The presence of the sulfur and of the aryl group was important for the inhibitory activity and the binding mode of a few compounds in VIM-2 was revealed by X-ray crystallography. Importantly, in vitro antibacterial susceptibility assays showed that several inhibitors were able to potentiate the activity of meropenem on Klebsiella pneumoniae clinical isolates producing VIM-1 or VIM-4, with a potentiation effect of up to 16-fold. Finally, a selected compound was found to only moderately inhibit the di-zinc human glyoxalase II, and several showed no or only moderate toxicity toward several human cells, thus favourably completing a promising behaviour.

Staudinger condensation for the preparation of thiohydantoins

An efficient one-pot, two-step sequence starting from azide derivatives is described: first, formation of iminophosphoranes (Staudinger reaction) and condensation with carbon disulfide to form nonisolated isothiocyanates; then, condensation with α-amino e