3876-45-7Relevant academic research and scientific papers
A CHIRAL, NON-RACEMIC C1-C7 ERYTHRONOLIDE SYNTHON USING THE 3-METHYL-γ-BUTYROLACTONE STRATEGY
Ziegler, Frederick E.,Kneisley, Alyssa
, p. 105 - 108 (2007/10/02)
A chiral, non-racemic C1-C7 unit for the synthesis of the erythronolides has been prepared.R-3-Methyl-γ-butyrolactone serves as the template for the synthesis.The stereochemistry at C3 of the synthon 13 was established by stereoselective, kinetic protonation of the enolates of lactones 9 and 10.
