103576-61-0

Upstream product

• 103576-57-4 tert-Butyl-((Z)-(R)-2-methyl-pent-3-enyloxy)-diphenyl-silane 
• 3876-45-7 Toluene-4-sulfonic acid (S)-2-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propyl ester 
• 95514-04-8 (R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol 
• 95514-03-7 (S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 115047-71-7 (4S,5R)-5-((S)-2-Hydroxy-1-methyl-ethyl)-4-methyl-dihydro-furan-2-one 
• 96259-00-6 4(R)-(1(S),4-dimethyl-2(E)-pentenyl)-2,2,5(S)-trimethyl-1,3-dioxane 
• 96258-99-0 2(S),4(S),7-trimethyl-5(E)-octene-1,3(R)-diol 
• 115115-35-0 (S)-3-((4R,5S)-2,2,5-Trimethyl-[1,3]dioxan-4-yl)-butyronitrile 
• 115181-73-2 (2S,3R,4S)-3,5-isopropylidenedioxy-2,4-dimethylpentanol 

Downstream Products

• 110410-93-0 3-carbomethoxy-4(S)-methyl-5(R)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone 
• 112452-64-9 6(S)-(1(S)-methyl-2-cyanoethyl)-4(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,2,5(S)-trimethyl-1,3-dioxane 
• 115047-32-0 7-<(tert-butyldimethylsilyl)oxy>-1-<(tert-butyldiphenylsilyl)oxy>-5-oxo-2(S),4(R),6(S)-trimethylheptan-3(S)-ol 
• 115047-31-9 3(R)-<1(R)-methyl-2-<(tert-butyldimethylsilyl)oxy>ethyl>-4(S)-methyl-5(R)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone 
• 115047-25-1 (E)-(2S,3S,4S,5S,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-2,4,6,9-tetramethyl-dec-7-ene-3,5-diol 
• 110455-56-6 3(S)-(1(S),4-dimethyl-2(E)-pentenyl)-4(S)-methyl-5(R)-<1(S)-methyl-2<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone 
• 110410-94-1 3(R)-(1(S),4-dimethyl-2(E)-pentenyl)-4(S)-methyl-5(R)-<1(S)-methyl-2<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone 
• 115047-26-2 (S)-3-{(4S,5S,6S)-6-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-butyric acid 
• 115076-42-1 6(R)-<1(S)-methyl-2-<(tert-butyldimethylsilyl)oxy>ethyl>-4(R)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,2,5(S)-trimethyl-1,3-dioxane 
• 115115-17-8 6(S)-(1(S)-methyl-2-hydroxyethyl)-4(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,2,5(S)-trimethyl-1,3-dioxane 
• 115047-25-1 (E)-(2S,3S,4S,5R,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-2,4,6,9-tetramethyl-dec-7-ene-3,5-diol 
• 115047-33-1 7-<(tert-butyldimethylsilyl)oxy>-1-<(tert-butyldiphenylsilyl)oxy>-2(S),4(S),6(S)-trimethylheptane-3(S),5(R)-diol 
• 115047-33-1 7-<(tert-butyldimethylsilyl)oxy>-1-<(tert-butyldiphenylsilyl)oxy>-2(S),4(S),6(S)-trimethylheptane-3(S),5(S)-diol 
• 110410-94-1 3(S)-(1(R),4-dimethyl-2(E)-pentenyl)-4(S)-methyl-5(R)-<1(S)-methyl-2<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone 

Relevant academic research and scientific papers

A CHIRAL, NON-RACEMIC C1-C7 ERYTHRONOLIDE SYNTHON USING THE 3-METHYL-γ-BUTYROLACTONE STRATEGY

A chiral, non-racemic C1-C7 unit for the synthesis of the erythronolides has been prepared.R-3-Methyl-γ-butyrolactone serves as the template for the synthesis.The stereochemistry at C3 of the synthon 13 was established by stereoselective, kinetic protonation of the enolates of lactones 9 and 10.

SYNTHETIC STUDIES TOWARDS THE ACYLTETRONIC ACID IONOPHORE M 139603

The synthesis of the optically pure tetrahydrofuran fragment of the acyltetronic acid ionophore M139603 from (S)-(+)-methyl-3- hydroxy-2-methylpropionate is described and its comparison made with authentic material derived from the natural product by degr