38767-27-0

Basic information

• Product Name: 4-ethoxy-α,α-dichloroacetophenone
• Synonyms: 4-ethoxy-α,α-dichloroacetophenone
• CAS NO: 38767-27-0
• Molecular Weight: 233.094
• Mol File: 38767-27-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-ethoxy-α,α-dichloroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethoxy-α,α-dichloroacetophenone(38767-27-0)
• EPA Substance Registry System: 4-ethoxy-α,α-dichloroacetophenone(38767-27-0)

Safety Data

• Hazardous Substances Data: 38767-27-0(Hazardous Substances Data)

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 103-73-1 Phenetole 

Downstream Products

• 70080-55-6 (4-ethoxy-phenyl)-glyoxylic acid 

Relevant articles and documents

Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships

Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.