38767-72-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-pyridin-2-ol is used as a key intermediate in the synthesis of nucleoside analogues, which possess significant antitumor and antiviral activity. These analogues are crucial in the development of medications for the treatment of various types of cancer and viral infections. 4-AMINO-PYRIDIN-2-OL's ability to be incorporated into nucleoside structures allows for the creation of effective therapeutic agents that can target and inhibit the replication of tumor cells and viruses.

Upstream product

• 2402-95-1 2-chloropyridine-N-oxide 
• 626-03-9 4-hydroxy-2-pyridone 
• 14432-16-7 2-chloro-4-nitropyridine-N-oxide 
• 109-09-1 2-chloropyridine 
• 14432-12-3 4-Amino-2-chloropyridine 
• 95306-61-9 4-Benzylamino-2-oxo-1,2-dihydropyridine 
• 855638-75-4 2-hydroxy-isonicotinoyl azide 

Downstream Products

• 129421-83-6 trans-3,4-dihydro-4-(4-amino-1,2-dihydro-2-oxo-1-pyridyl)-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile 
• 130378-88-0 (1'R,4'R,5'S)-1-[3-(hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]-4-amino-2-pyridone 
• 959984-55-5 3-methoxy-4-(2-methyl-3-nitro-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl)benzonitrile 
• 959984-42-0 3-acetyl-2-methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]-4,6-dihydro-1,6-naphthyridin-5(1H)-one 
• 959984-40-8 4-(4-cyano-2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile 
• 959984-54-4 4-(4-cyano-2-methoxyphenyl)-5-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile 
• 959984-32-8 4-(3-acetyl-2-methyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl)benzonitrile 
• 959984-30-6 2-methyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile 
• 959984-28-2 3-acetyl-2-methyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-4,6-dihydro-1,6-naphthyridin-5(1H)-one 
• 959984-31-7 4-(3-acetyl-2-methyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl)-3-methoxybenzonitrile 
• 959984-29-3 4-(3-acetyl-2-methyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl)-3-(trifluoromethoxy)benzonitrile 
• 959984-39-5 4-(3-acetyl-2-methyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl)-3-ethylbenzonitrile 
• 959984-43-1 4-(3-acetyl-2-methyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl)-3-fluorobenzonitrile 
• 959984-44-2 4-(3-acetyl-2-methyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl)-3-chlorobenzonitrile 

Relevant academic research and scientific papers

Concise Entries to 4-Halo-2-pyridones and 3-Bromo-4-halo-2-pyridones

Methods for the synthesis of both simple 4-halo-2-pyridones and more functionalized 3,4-di- and (3,4,5-tri)-halo-2-pyridones are described that are based on a combination of Sandmeyer and regioselective (copper-mediated) halogenation, with a 2-chloro or a 2-benzyloxy moiety serving as a masked 2-pyridone.

Synthesis of the analogue nucleoside 3-deaza-2'-deoxycytidine and its template activity with DNA polymerase

A new synthesis of the nucleoside analogue 3-deaza-2'-deoxycytidine is described. The N3-nitrogen of dC is involved in the central hydrogen bond of a dG-dC base pair. The relative importance of hydrogen bonding as a controlling factor in the activity of DNA polymerase is examined by studying both duplex stability and template effects for this dc3C nucleoside. Duplexes containing dG-dc3C base pairs were strongly destabilized while templates containing the analogue nucleoside were found to incorporate only the complementary dG triphosphate, similar to observations with templates containing the native 2'-deoxycytidine.