38767-72-5

Basic information

• Product Name: 4-AMINO-PYRIDIN-2-OL
• Synonyms: 3-DEAZACYTOSINE;4-AMINO-PYRIDIN-2-OL;4-AMINO-2-PYRIDONE;4-AMINO-2-HYDROXYPYRIDINE;3-Deazacytosine 4-Amino-2-pyridone;4-Amino-2-hydroxy prydine;4-AMINO-2-HYDROXYPYRIDINE 98%;2(1H)-Pyridinone, 4-amino-
• CAS NO: 38767-72-5
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11
• Product Categories: Nitrogen cyclic compounds;pharmacetical;Pyridine;API intermediates;Pyridines;Heterocycle-Pyridine series
• Mol File: 38767-72-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 219-221 °C(Solv: acetone (67-64-1))
• Boiling Point: 310.7 °C at 760 mmHg
• Flash Point: 141.7 °C
• Appearance: /
• Density: 1.208 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 11.49±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-PYRIDIN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-PYRIDIN-2-OL(38767-72-5)
• EPA Substance Registry System: 4-AMINO-PYRIDIN-2-OL(38767-72-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 38767-72-5(Hazardous Substances Data)

Usage

Uses

4-Amino-2-pyridone is used in the preparation of nucleoside analogues with antitumor and antiviral activity.

Upstream product

• 855638-75-4 2-hydroxy-isonicotinoyl azide 
• 2402-95-1 2-chloropyridine-N-oxide 
• 626-03-9 4-hydroxy-2-pyridone 
• 14432-16-7 2-chloro-4-nitropyridine-N-oxide 
• 109-09-1 2-chloropyridine 
• 14432-12-3 4-Amino-2-chloropyridine 
• 95306-61-9 4-Benzylamino-2-oxo-1,2-dihydropyridine 

Downstream Products

• 129421-83-6 trans-3,4-dihydro-4-(4-amino-1,2-dihydro-2-oxo-1-pyridyl)-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile 
• 107842-77-3 4-amino-3-chloro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone 
• 107842-75-1 4-amino-3-bromo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone 
• 107842-78-4 4-amino-3-chloro-1-β-D-ribofuranosyl-2(1H)-pyridinone 
• 107842-76-2 4-amino-3-bromo-1-β-D-ribofuranosyl-2(1H)-pyridinone 
• 1050477-49-0 2-cyanoethyl 4-[4-bromo-2-(trifluoromethoxy)phenyl]-2-methyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate 
• 1050477-35-4 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate 
• 1050477-46-7 2-cyanoethyl 2-methyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate 
• 1163176-12-2 2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-5-oxo-4-(1H-pyrazol-3-yl)-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile 
• 1163176-13-3 4-[4-(2-Hydroxyethoxy)phenyl]-2-(methylsulfanyl)-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carbonitrile 
• 1163175-80-1 2-({[2-(4-Chlorophenyl)-1,3-oxazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carbonitrile 
• 1163175-94-7 2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-5-oxo-4-(1H-pyrazol-3-yl)-5,6-dihydro-1,6-naphthyridine-3-carbonitrile 
• 1163175-95-8 2-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methoxy}-4-[4-(2-hydroxyethoxy)phenyl]-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carbonitrile 
• 1163175-98-1 4-[4-(2-Hydroxyethoxy)phenyl]-2-mercapto-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carbonitrile 

Relevant articles and documents

Concise Entries to 4-Halo-2-pyridones and 3-Bromo-4-halo-2-pyridones

Methods for the synthesis of both simple 4-halo-2-pyridones and more functionalized 3,4-di- and (3,4,5-tri)-halo-2-pyridones are described that are based on a combination of Sandmeyer and regioselective (copper-mediated) halogenation, with a 2-chloro or a 2-benzyloxy moiety serving as a masked 2-pyridone.

A General Route to 5- and 6-Substituted 4-Amino-2-oxo-1,2-dihydropyridines

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