2974-94-9

Basic information

• Product Name: 4-IODODIPHENYL ETHER
• Synonyms: 4-IODODIPHENYL ETHER;1-IODO-4-PHENOXY-BENZENE;4-Iodophenyl phenylether;4-Phenoxyphenyl iodide;4-Phenoxyiodobenzene;Phenyl iodophenyl ether;p-Phenoxyiodobenzene
• CAS NO: 2974-94-9
• Molecular Formula: C₁₂H₉IO
• Molecular Weight: 296.10373
• Product Categories: API intermediates
• Mol File: 2974-94-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 43～45℃
• Boiling Point: 317.6 °C at 760 mmHg
• Flash Point: 145.9 °C
• Appearance: /
• Density: 1.626 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4-IODODIPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODODIPHENYL ETHER(2974-94-9)
• EPA Substance Registry System: 4-IODODIPHENYL ETHER(2974-94-9)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 2974-94-9(Hazardous Substances Data)

Usage

General Description

4-Iododiphenyl ether, also known as bis(4-iodophenyl) ether, is a chemical compound consisting of two phenyl rings connected by an oxygen atom, with an iodine atom attached to each phenyl ring. It is used as a reactant in the synthesis of various organic compounds, including pharmaceuticals, dyes, and polymers. The presence of iodine atoms in the molecule makes it useful for applications such as cross-coupling reactions and as a precursor for the synthesis of functional materials. 4-Iododiphenyl ether is considered to be a hazardous chemical due to its potential for causing skin and eye irritation, as well as its toxic effects when inhaled or ingested. Therefore, proper handling and disposal procedures are necessary when working with this compound.

InChI:InChI=1/C18H13IO/c19-15-12-10-14(11-13-15)17-8-4-5-9-18(17)20-16-6-2-1-3-7-16/h1-13H

Upstream product

• 101-84-8 diphenylether 
• 139-59-3 4-phenoxyanilin 
• 696-62-8 para-iodoanisole 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 540-38-5 p-Iodophenol 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 639-58-7 triphenyltin chloride 
• 98-95-3 nitrobenzene 
• 624-38-4 para-diiodobenzene 
• 108-95-2 phenol 
• 106-37-6 1.4-dibromobenzene 
• 66003-76-7 Diphenyliodonium triflate 
• 591-50-4 iodobenzene 
• 620-88-2 4-nitrophenyl phenyl ether 

Downstream Products

• 28896-49-3 bis(4-iodophenyl) ether 
• 21969-05-1 1-(4-nitrophenoxy)-4-iodobenzene 
• 854257-01-5 1-chloro-4-(4-iodophenoxy)benzene 
• 220025-13-8 1-bromo-4-(4-iodophenoxy)benzene 
• 69199-91-3 5-iodo-2-phenoxy-benzoic acid 
• 101-84-8 diphenylether 
• 67-36-7 4-phenoxy benzaldehyde 
• 163404-62-4 B₁₀H₁₀C₂(C₆H₄OC₆H₄CCC₆H₄OC₆H₅)2 
• 1199939-46-2 1-methyl-5-(4-phenoxyphenyl)-1H-1,2,4-triazole 
• 330-84-7 4-fluorophenoxybenzene 
• 4973-29-9 4-phenoxystyrene 
• 2215-77-2 4-Phenoxybenzoic acid 
• 38778-05-1 4-(Phenoxy)benzenethiol 
• 620-88-2 4-nitrophenyl phenyl ether 

Relevant articles and documents

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One-Pot, Metal-Free Conversion of Anilines to Aryl Bromides and Iodides

A metal-free synthesis of aryl bromides and iodides from anilines via halogen abstraction from bromotrichloromethane and diiodomethane is described. This one-pot reaction affords aryl halides from the corresponding anilines in moderate to excellent yields without isolation of diazonium salts. The transformation has short reaction times, a simple workup, and insensitivity to moisture and air and avoids excess halogenation. DFT calculations support a SRN1 mechanism. This method represents a convenient alternative to the classic Sandmeyer reaction.

An in situ acidic carbon dioxide/glycol system for aerobic oxidative iodination of electron-rich aromatics catalyzed by Fe(NO3)3·9H2O

An environmentally benign CO2/glycol reversible acidic system was developed for the iron(iii)-catalyzed aerobic oxidative iodination of electron-rich aromatics without the need for any conventional acid additive or organic solvent. Notably, moderate to high isolated yields (up to 97%) of the aryl iodides were attained with comparable regioselectivity when ferric nitrate nonahydrate was used as the catalyst with molecular iodine under 1 MPa of CO2.