38779-78-1

Usage

Structure

A five-membered imidazole ring with two nitrogen atoms, a hydroxy group, a dimethyl group, and a phenyl group attached to the ring.

Usage

Organic synthesis, pharmaceutical research, and potential applications in medicinal chemistry.

Possible pharmacological activities

The compound may exhibit various pharmacological activities.

Potential use in drug development

Due to its structural and biological properties, it could be useful in the development of new drugs.

Upstream product

• 22147-53-1 N-(benzylidene)-N-(2-hydroxyimino-1-methylpropyl)amine-N-oxide 
• 100-52-7 benzaldehyde 
• 135636-66-7 butane-2,3-dione mono-oxime 

Downstream Products

• 13682-20-7 4,5-dimethyl-2-phenyl-1H-imidazole 
• 1395070-55-9 C₂₂H₃₁N₃O₃ 
• 1365609-23-9 6-(4-(((4,5-dimethyl-2-phenyl-1H-imidazol-1-yl)oxy)methyl)piperidin-1-yl)-9-methyl-8-(1-methyl-1H-pyrazol-4-yl)-9H-purine 
• 1365609-24-0 4-((4,5-dimethyl-2-phenyl-1H-imidazol-1-yloxy)methyl)piperidine hydrochloride 

Relevant academic research and scientific papers

Synthesis of 2-aryl(hetaryl)-1-hydroxyimidazoles by the reaction of aliphatic 1,2-hydroxylamino oximes with aromatic and heteroaromatic aldehydes

A reaction of aliphatic 1,2-hydroxylamino oximes bearing the hydroxylamino group at the secondary carbon atom with aromatic and heteroaromatic aldehydes in acetic acid leads to the corresponding 1-hydroxy-2-aryl(hetaryl)-4,5- dialkylimidazoles in high yields. α-Aryl(hetaryl)-nitrones initially formed by the condensation of 1,2-hydroxylamino oximes with aldehydes are quantitatively converted to the corresponding imidazoles.

INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE

The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.