3878-24-8Relevant articles and documents
Design, Microwave-Assisted Synthesis and in Vitro Antibacterial and Antifungal Activity of 2,5-Disubstituted Benzimidazole
Shi, Yanpeng,Jiang, Kai,Zheng, Ran,Fu, Jiaxu,Yan, Liuqing,Gu, Qiang,Zhang, Yumin,Lin, Feng
, (2019/02/13)
Seventeen novel 2,5-disubstituted benzimidazole derivatives were designed, synthesized and evaluated for their antibacterial activities. The tested compounds B1–B4 and C2–C6 exhibited not only good antifungal activity but also favorable broad-spectrum antibacterial activity. Also, the lowest MIC of antibacterial and antifungal activity was 2 μg/mL and 4 μg/mL, respectively. It suggested that the structure of compound including the different substituent and its sites directly affected the efficacy of the synthesized compounds.
Br?nsted acid-catalyzed metal-free one-pot synthesis of benzimidazoles via [4+1] heteroannulation of ortho-phenylenediamines with β-oxodithioesters
Srivastava, Abhijeet,Shukla, Gaurav,Yadav, Dhananjay,Singh, Maya Shankar
, p. 81 - 89 (2018/02/07)
An operationally simple and user-friendly one-pot domino protocol for the synthesis of 2-aryl/hetaryl benzimidazoles has been devised from easily available and inexpensive 1,2-phenylenediamines and β-oxodithioesters. The strategic [4+1] heteroannulation i
DBSA mediated chemoselective synthesis of 2-substituted benzimidazoles in aqueous media
Kumar, Vikash,Khandare, Dipratn G.,Chatterjee, Amrita,Banerjee, Mainak
, p. 5505 - 5509 (2013/09/23)
An efficient synthetic method has been developed for the facile synthesis of 2-substituted benzimidazoles in organized aqueous media in the presence of a surfactant (viz. DBSA) as catalyst and I2 as co-catalyst. The method described has the advantages of operational simplicity, excellent yields, high chemoselectivity, and clean and green reaction profile.
