387818-15-7Relevant articles and documents
Simple synthesis of N-alkoxymethyl derivatives of anilides
Danikiewicz,Szmigielski
, p. 3047 - 3054 (2001)
Facile, two-step synthesis of N-alkoxymethyl derivatives of anilides consisting of the methoxymethylation of the appropriate anilides with chlomethyl methyl ether followed by heating with an alcohol in the presence of an acid is described.
N-alkoxymethylation of secondary amides, sulfonamides and phosphamides using dialkoxymethanes in the presence of Lewis acids
Szmigielski, Rafa?,Danikiewicz, Witold
, p. 372 - 376 (2007/10/03)
A convenient and efficient one-pot synthesis of N-alkoxymethyl derivatives of secondary amides, sulfonamides and phosphamides in reaction with the appropriate dialkoxymethanes in the presence of a Lewis acid is described. In this method the use of toxic and carcinogenic chloromethyl alkyl ethers was eliminated.