387847-38-3Relevant academic research and scientific papers
1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: Synthesis, characterization and its biological studies
Harikrishna,Isloor, Arun M.,Ananda,Obaid, Abdulrahman,Fun, Hoong-Kun
, p. 43648 - 43659 (2015)
A new series 3-{2-[N′-(1,3-disubstituted-1H-pyrazol-4-yl-methylene)-hydrazino]-thiazol-4-yl}-chromen-2-one (10a-l) was synthesized by a multi-step reaction. All the synthesized compounds were characterized by IR, NMR, and mass spectral studies, followed by elemental analysis. The newly synthesized thiazole compounds were screened for their in vitro antibacterial and antifungal studies against various microorganisms. Antimicrobial studies carried out by the well diffusion method, showed a very good zone of inhibition for both bacteria (at a range of 20-50 mm diameter) and fungi (at a range of 10-30 mm diameter). Minimum Inhibitory Concentration (MIC) required for the 100% inhibition of bacteria and fungi was found to be as low as 15.6 μg ml-1 for a few of the synthesized compounds.
Synthesis and antihyperglycemic evaluation of new 2-hydrazolyl-4- thiazolidinone-5-carboxylic acids having pyrazolyl pharmacophores
Bhosle, Manisha R.,Mali, Jyotirling R.,Pal, Savita,Srivastava, Arvind K.,Mane, Ramrao A.
, p. 2651 - 2654 (2014/06/09)
In the search of new antihyperglycemic agents and following rational approach of drug designing here new 2-hydrazolyl-4-thiazolidinone-5-carboxylic acids (4a-g) with pyrazolyl pharmacophore have been synthesized via thia Michael addition reaction of 1-((3
Novel bioactive thio- and semicarbazide ligands and their organosilicon (IV) complexes
Sonika,Meenakshi,Malhotra, Rajesh
experimental part, p. 1875 - 1885 (2010/11/04)
Ligational behavior of thiosemicarbazones and semicarbazones derived from 1-phenyl-3-arylpyrazole-4-carboxaldehydes towards triphenylchlorosilane has been investigated by elemental analysis, molar conductivity measurements, and IR, 1H, 13C, and 29Si NMR spectroscopic studies. The ligands and their organosilicon complexes have also been evaluated for in vitro antimicrobial activity against some pathogenic bacteria and fungi. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright
One-pot synthesis of some new semicarbazone, thiosemicarbazone, and hydrazone derivatives of 1-phenyl-3-arylpyrazole-4-carboxaldehyde from acetophenone phenylhydrazones using Vilsmeier-Haack reagent
Pundeer, Rashmi,Ranjan, Pooja,Pannu, Kamaljeet,Prakash, Om
experimental part, p. 316 - 324 (2009/05/09)
Semicarbazone derivatives 3 of 1,3-diphenylpyrazole-4-carboxaldehyde have been synthesized in high yields through a one-pot procedure involving acetophenone phenylhydrazones 1 subjected to Vilsmeier double formylation and workup under new conditions (i.e., treatment with semicarbazide followed by sodium bicarbonate). This method is even suitable for preparing other derivatives (i.e., thiosemicarbazones 4 and hydrazones 5) in high yields. Copyright Taylor & Francis Group, LLC.
