38792-42-6

Basic information

• Product Name: N-CHLOROMETHYL-BENZAMIDE
• Synonyms: N-CHLOROMETHYL-BENZAMIDE
• CAS NO: 38792-42-6
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.60822
• Mol File: 38792-42-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-CHLOROMETHYL-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CHLOROMETHYL-BENZAMIDE(38792-42-6)
• EPA Substance Registry System: N-CHLOROMETHYL-BENZAMIDE(38792-42-6)

Safety Data

• Hazardous Substances Data: 38792-42-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 27, p. 1251, 1986 DOI: 10.1016/S0040-4039(00)84230-6

Upstream product

• 6282-02-6 N-(hydroxymethyl)benzamide 
• 55-21-0 benzamide 

Downstream Products

• 29272-68-2 (E)-N-(3-(4-methoxyphenyl)allyl)benzamide 
• 29360-74-5 2-phenyl-6-p-tolyl-5,6-dihydro-4H-[1,3]oxazine 
• 29360-44-9 6-methyl-2-phenyl-5,6-dihydro-4H-[1,3]oxazine-6-carboxylic acid methyl ester 
• 4604-16-4 2,6-diphenyl-4H-[1,3]oxazine 
• 29360-41-6 2-Benzaminomethyl-inden 
• 29272-83-1 2-phenyl-(4ar,9bc)-4,4a,5,9b-tetrahydro-indeno[2,1-e][1,3]oxazine 
• 29272-79-5 1-(2,6t-diphenyl-5,6-dihydro-4H-[1,3]oxazin-5r-yl)-ethanone 
• 103635-47-8 C₉H₁₁N₃O₃ 
• 103635-48-9 C₁₀H₁₃N₃O₃ 
• 51643-77-7 benzamidomethyl benzyl sulphide 
• 191664-12-7 N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-3-methyl-butyl]-benzamide 
• 191664-13-8 N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide 
• 191664-11-6 N-[(R)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-methyl-3-oxo-propyl]-benzamide 
• 210345-88-3 (R)-2-(Benzoylamino-methyl)-4-methyl-pentanoic acid 

Relevant articles and documents

BIM-46174 fragments as potential ligands of G proteins

The 5,6,7,8-Tetrahydroimidazo[1,2-A]pyrazine derivative BIM-46174 has received attention as Gαq inhibitor. We conducted structural reductions to monocyclic and bicyclic substructures to explore the chemical space of BIM fragments and to gain insights into the pharmacophore of BIM-Type Gαq inhibitors. Two piperazin-2-one-containing fragments and a small library of bicyclic lactams featuring fused pyrazine and diazepine rings were synthesized and evaluated. The results of a second messenger-based cellular assay indicate that the entire BIM structure is required for efficient Gαq inhibition.

Asymmetric synthesis of optically active methyl-2-benzamido-methyl-3-hydroxy-butyrate by robust short-chain alcohol dehydrogenases from Burkholderia gladioli

Three short-chain alcohol dehydrogenases from Burkholderia gladioli were discovered for their great potential in the dynamic kinetic asymmetric transformation of methyl 2-benzamido-methyl-3-oxobutanoate, and their screening against varied organic solvents and substrates. This is the first report of recombinant enzymes capable of achieving this reaction with the highest enantio- and diastereo-selectivity.

3-(Hydroxy(phenyl)methyl)azetidin-2-ones obtained via catalytic asymmetric hydrogenation or by biotransformation

The catalytic asymmetric reduction of ethyl-2-(benzamidomethyl)-3-oxo- phenylpropanoate was realized with high enantiomeric and diastereoisomeric excesses via biotransformation using whole cells of different yeasts and asymmetric hydrogenation with Ru(II)