388073-76-5Relevant academic research and scientific papers
Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human β-secretase
Maillard, Michel C.,Hom, Roy K.,Benson, Timothy E.,Moon, Joseph B.,Mamo, Shumeye,Bienkowski, Michael,Tomasselli, Alfredo G.,Woods, Danielle D.,Prince, D. Bryan,Paddock, Donna J.,Emmons, Thomas L.,Tucker, John A.,Dappen, Michael S.,Brogley, Louis,Thorsett, Eugene D.,Jewett, Nancy,Sinha, Sukanto,John, Varghese
, p. 776 - 781 (2007)
The design and synthesis of a novel series of potent and cell permeable peptidomimetic inhibitors of the human β-secretase (BACE) are described. These inhibitors feature a hydroxyethyl secondary amine isostere and a novel aromatic ring replacement for the
