388077-30-3

Upstream product

• 62-53-3 aniline 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 

Downstream Products

• 388077-41-6 ethyl 4,4,4-trifluoro-2-methyl-3-(phenylamino)butanoate 
• 1693-90-9 N-(2,2,2-Trifluor-1-methyl-aethyl)-anilin 
• 771535-08-1 4,4,4-trifluoro-3-(phenylamino)butanoic acid 
• 771535-03-6 Diethyl 2-(2,2,2-trifluoro-1-(phenylamino)ethyl)malonate 

Relevant academic research and scientific papers

New synthesis of 2-trifluoromethyl-2,3-dihydro-1H-quinolin-4-ones

N-(1-Ethoxy-2,2,2-trifluoroethyl)anilines 2a-2f, prepared from trifluoroacetaldehyde ethyl hemiacetal and aniline, readily reacted with diethyl malonate in the presence of sodium hydride, giving substituted products 5a-5f in high yields. Compounds 5a-5f s

Nucleophilic reactions with α-trifluoromethyl imine and N,O-disubstituted aminal: Synthesis of β-trifluoromethyl β-anilino esters

The Reformatsky reaction with 4-methoxy-N-(2,2,2-trifluoroethylidene)aniline (1) proceeds under mild conditions to yield ethyl 4,4,4-trifluoro-3-(N-4-methoxyphenyl)amino-2-alkylbutyrate (5) and 4-trifluoromethyl-3-alkyl-1-(4-methoxyphenyl)-2-azetidinone (