771535-08-1Relevant academic research and scientific papers
Identification of potent and selective VEGFR receptor tyrosine kinase inhibitors having new amide isostere headgroups
Gaudette, Frederic,Raeppel, Stephane,Nguyen, Hannah,Beaulieu, Normand,Beaulieu, Carole,Dupont, Isabelle,Macleod, A. Robert,Besterman, Jeffrey M.,Vaisburg, Arkadii
scheme or table, p. 848 - 852 (2010/09/08)
A novel series of malonamide-type dual VEGFR2/c-Met inhibitors in which one of the amide bonds was replaced by an amide isostere-a trifluoroethylamine unit, was designed, synthesized, and evaluated for their enzymatic and cellular inhibition of VEGFR2 and c-Met enzymes. Optimization of these molecular entities resulted in identification of potent and selective inhibitors of VEGFR2 enzyme.
Inhibitors of VEGF receptor and HGF receptor signaling
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Page/Page column 157-158, (2010/11/25)
The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions
New synthesis of 2-trifluoromethyl-2,3-dihydro-1H-quinolin-4-ones
Gong, Yuefa,Kato, Katsuya
, p. 767 - 773 (2007/10/03)
N-(1-Ethoxy-2,2,2-trifluoroethyl)anilines 2a-2f, prepared from trifluoroacetaldehyde ethyl hemiacetal and aniline, readily reacted with diethyl malonate in the presence of sodium hydride, giving substituted products 5a-5f in high yields. Compounds 5a-5f s
