38817-29-7 Usage
Uses
Used in Oncology:
5'-Deoxy-5-fluorouridine is used as an anticancer agent for the treatment of various solid tumors, particularly breast, colon, and gastrointestinal (GI) cancers. It is effective due to its ability to interfere with DNA replication in cancer cells, causing their destruction.
However, the use of 5'-Deoxy-5-fluorouridine comes with the risk of serious side effects and toxicity, which may include gastrointestinal issues, bone marrow suppression, and neurotoxicity. Therefore, its administration in a medical setting requires close monitoring and expert handling to ensure patient safety and therapeutic efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 38817-29-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,8,1 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 38817-29:
(7*3)+(6*8)+(5*8)+(4*1)+(3*7)+(2*2)+(1*9)=147
147 % 10 = 7
So 38817-29-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H11FN2O5/c10-3-4-6(14)7(15)8(17-4)12-2-1-5(13)11-9(12)16/h1-2,4,6-8,14-15H,3H2,(H,11,13,16)
38817-29-7Relevant academic research and scientific papers
Fluorinase-coupled base swaps: Synthesis of [18F]-5′- deoxy-5′-fluorouridines
Winkler, Margit,Domarkas, Juozas,Schweiger, Lutz F.,O'Hagan, David
supporting information; experimental part, p. 10141 - 10143 (2009/05/30)
(Chemical Equation Presented) Making F-ases: One-pot fluorination/base-swap biotransformations were developed by coupling the fluorinase enzyme to nucleoside phosphorylases to generate 5′-deoxy-5′-fluoronucleosides (FDAs). These biotransformations are amenable to radiolabeling syntheses starting from [18F]fluoride ion, as exemplified by the synthesis of [18F]-5′-deoxy-5′-fluorouridines (see scheme), and demonstrate a new application of fluorinase as a catalyst for 18F-C bond formation.
