3882-48-2

Upstream product

• 3882-45-9 2-nitrophenyl pyridin-3-yl ketone 
• 552-89-6 2-nitro-benzaldehyde 
• 118-92-3 anthranilic acid 

Downstream Products

• 1058743-85-3 {tert-Butoxycarbonylamino-[2-(pyridine-3-carbonyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester 
• 280568-18-5 {Benzotriazol-1-yl-[2-(pyridine-3-carbonyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester 
• 827575-86-0 N-[4-({[2-(pyridin-3-ylcarbonyl)phenyl]amino}sulfonyl)phenyl]acetamide 
• 3882-46-0 5H-indeno[1,2-b]pyridin-5-one 
• 280568-19-6 (1-Methyl-2-oxo-5-pyridin-3-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester 
• 1061237-45-3 {Amino-[2-(pyridine-3-carbonyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester 
• 155412-20-7 [1-(2-Cyclopentyl-2-oxo-ethyl)-2-oxo-5-pyridin-3-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester 
• 173459-81-9 3-(benzyloxycarbonyl-amino)-5-pyridin-3-yl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 

Relevant academic research and scientific papers

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Method for synthesizing ortho-amino aromatic ketone from aromatic carboxylic acid

Disclosed is a method for synthesizing ortho-amino aromatic ketone from aromatic carboxylic acid. The method comprises the steps that with 2-arylsulfonamido aromatic carboxylic acid shown in the description as a raw material and triphenylphosphine as a deoxidizer, under the illumination of blue light, in a 1,4-dioxane solution, under an argon atmosphere, in the presence of the dipotassium hydrogenphosphate, with [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 as a photocatalyst, the ortho-amino aromatic ketone compound is obtained; the structure of the photocatalyst [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 is shown in thedescription.

An investigation on the second-order NLO properties of novel cationic cyclometallated Ir(III) complexes of the type [Ir(2-phenylpyridine) 2(9-R-4,5-diazafluorene)]+ (R = H, fulleridene) and the related neutral complex with the new 9-fulleriden-4-monoazafluorene ligand

Novel cationic cyclometallated Ir(III) complexes bearing diaza- or monoazafluorene substituted or not with a C60-fullerene moiety have been synthesized together with a novel interesting ligand 9-fulleriden-4- monoazafluorene and the related Ir(III) neutral complex [Ir(ppy) 2(9-fulleriden-4-monoazafluorene)]. All complexes show a negative large value of μβ1.907 (-600 to -2190 × 10 -48 esu), as determined by the Electric Field Induced Second Harmonic generation (EFISH) technique working at 1.907 μm in 10-3 M CH2Cl2 solution. The NLO response increases upon introduction of the fullerene moiety, due to a decrease of the interaction forces between the anion and cation within the ion pair which leads to an increase of the percentage of free ions, as evidenced by diffusion NMR experiments. Besides, it appeared that for the neutral complex [Ir(ppy) 2(9-fulleriden-4-monoazafluorene)] the EFISH μβ 1.907 value is lower than that of cationic Ir(III) complexes, but comparable or slightly lower to the values of other neutral Ir(III) complexes such as [Ir(ppy)2(RCOCR′COR)] (ppy = cyclometallated 2-phenylpyridine; R = Me, Ph; R′ = H, 2,4-dinitrophenyl), confirming that the second-order NLO response of these neutral chromophores is dominated by ILCT processes concerning cyclometallated 2-phenylpyridines.

Succinoylaminobenzodiazepines as inhibitors of Abeta protein production

This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

Benzodiazepine derivatives useful as CCK-receptor antagonists

This invention relates to benzodiazepine derivatives which are useful as drugs exhibiting antagonism at the gastrin and/or CCK-B receptor, and to their production.

Cyclising Nucleophilic Addition to Azinium Systems. Part 2. Reactions of 3-Acylpyridinium Hydrazones.

3-Acyl-1-methylpyridinium tosyl- and benzoylhydrazines lose a side-chain N-hydrogen on treatment with mild base thus forming zwitterions, isolable in some cases; intramolecular nucleophilic cyclising addition to the pyridinium nucleus in these was observe

[2-[(Nitropyridinyl)amino]phenyl]arymethanones

[2-[(Nitropyridinyl)amino]phenyl]arylmethanones as chemical intermediates and/or having antidepressant activity having the formula: STR1 wherein: B is carbonyl, thioxomethyl, ketal or thioketal, R is hydrogen or -alk1 -Q, Q is hydrogen, --NR1 R2 or halogen are disclosed in a process for preparing pyrido[1,4]benzodiazepines.